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Chronic Paronychia and Onychomadesis in Pemphigus Vegetans : An Unusual Presentation in a Rare Autoimmune Disease

Sukakul, Thanisorn LU orcid and Varothai, Supenya (2018) In Case Reports in Medicine 2018.
Abstract

Pemphigus vegetans is a rare variant of deep acantholytic pemphigus which usually presents with vesiculobullous rash and vegetative plaques on the folds. We report a case of pemphigus vegetans patient who presented with rashes on tips of fingers and toes resembling paronychia and onychomadesis that misled the diagnosis for months. The final diagnosis of Hallopeau-type pemphigus vegetans was made based on histopathology and direct immunofluorescence studies. Interestingly, not only the clinical presentation was atypical, but blood tests for anti-desmoglein 1 and 3 antibodies by ELISA technique were also negative. Thus, the rare unusual manifestation of pemphigus vegetans in this patient may associate with different autoantibodies to... (More)

Pemphigus vegetans is a rare variant of deep acantholytic pemphigus which usually presents with vesiculobullous rash and vegetative plaques on the folds. We report a case of pemphigus vegetans patient who presented with rashes on tips of fingers and toes resembling paronychia and onychomadesis that misled the diagnosis for months. The final diagnosis of Hallopeau-type pemphigus vegetans was made based on histopathology and direct immunofluorescence studies. Interestingly, not only the clinical presentation was atypical, but blood tests for anti-desmoglein 1 and 3 antibodies by ELISA technique were also negative. Thus, the rare unusual manifestation of pemphigus vegetans in this patient may associate with different autoantibodies to desmosomal proteins compared with those of classic pemphigus patients.

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author
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publishing date
type
Contribution to journal
publication status
published
subject
in
Case Reports in Medicine
volume
2018
article number
5980937
publisher
Hindawi Limited
external identifiers
  • scopus:85042653342
ISSN
1687-9627
DOI
10.1155/2018/5980937
language
English
LU publication?
no
additional info
Publisher Copyright: © 2018 Thanisorn Sukakul and Supenya Varothai.
id
382127bf-c2bb-4b86-90ce-5bc129e81a7c
date added to LUP
2024-07-15 14:34:18
date last changed
2024-07-16 13:43:55
@article{382127bf-c2bb-4b86-90ce-5bc129e81a7c,
  abstract     = {{<p>Pemphigus vegetans is a rare variant of deep acantholytic pemphigus which usually presents with vesiculobullous rash and vegetative plaques on the folds. We report a case of pemphigus vegetans patient who presented with rashes on tips of fingers and toes resembling paronychia and onychomadesis that misled the diagnosis for months. The final diagnosis of Hallopeau-type pemphigus vegetans was made based on histopathology and direct immunofluorescence studies. Interestingly, not only the clinical presentation was atypical, but blood tests for anti-desmoglein 1 and 3 antibodies by ELISA technique were also negative. Thus, the rare unusual manifestation of pemphigus vegetans in this patient may associate with different autoantibodies to desmosomal proteins compared with those of classic pemphigus patients.</p>}},
  author       = {{Sukakul, Thanisorn and Varothai, Supenya}},
  issn         = {{1687-9627}},
  language     = {{eng}},
  publisher    = {{Hindawi Limited}},
  series       = {{Case Reports in Medicine}},
  title        = {{Chronic Paronychia and Onychomadesis in Pemphigus Vegetans : An Unusual Presentation in a Rare Autoimmune Disease}},
  url          = {{http://dx.doi.org/10.1155/2018/5980937}},
  doi          = {{10.1155/2018/5980937}},
  volume       = {{2018}},
  year         = {{2018}},
}