Correlations between cholinergic neurons and muscarinic m2 receptors in the rat retina
(1998) In NeuroReport 9(8). p.802-1799- Abstract
Acetylcholine is well established as the neurotransmitter of starburst amacrine cells in the vertebrate retina but their function is poorly understood. We compared the distribution of muscarinic m2 receptors in the rat retina with the localization of the starburst cell processes. mAChR2 immunoreactivity appeared in a central band in the inner plexiform layer, which did not co-localize with the processes of the cholinergic amacrine cells. We found co-labelling of VAChT and ChAT making it highly unlikely that there are undetected cholinergic neurons in rat retina. Most mAChR2 receptors were located far from the cholinergic neurons, suggesting that most of them are unlikely to be associated with conventional cholinergic synapses.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/385e00c5-f536-4305-b1e6-1f4dd1b61498
- author
- Wassélius, J LU ; Johansson, Kjell LU ; Bruun, A LU ; Zucker, C and Ehinger, B LU
- organization
- publishing date
- 1998-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acetylcholine, Animals, Choline O-Acetyltransferase, Female, Neurons, Rats, Rats, Sprague-Dawley, Receptors, Muscarinic, Retina, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
- in
- NeuroReport
- volume
- 9
- issue
- 8
- pages
- 4 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:9665603
- scopus:0032104066
- ISSN
- 0959-4965
- language
- English
- LU publication?
- yes
- id
- 385e00c5-f536-4305-b1e6-1f4dd1b61498
- date added to LUP
- 2016-10-14 10:02:03
- date last changed
- 2024-01-04 14:20:33
@article{385e00c5-f536-4305-b1e6-1f4dd1b61498, abstract = {{<p>Acetylcholine is well established as the neurotransmitter of starburst amacrine cells in the vertebrate retina but their function is poorly understood. We compared the distribution of muscarinic m2 receptors in the rat retina with the localization of the starburst cell processes. mAChR2 immunoreactivity appeared in a central band in the inner plexiform layer, which did not co-localize with the processes of the cholinergic amacrine cells. We found co-labelling of VAChT and ChAT making it highly unlikely that there are undetected cholinergic neurons in rat retina. Most mAChR2 receptors were located far from the cholinergic neurons, suggesting that most of them are unlikely to be associated with conventional cholinergic synapses.</p>}}, author = {{Wassélius, J and Johansson, Kjell and Bruun, A and Zucker, C and Ehinger, B}}, issn = {{0959-4965}}, keywords = {{Acetylcholine; Animals; Choline O-Acetyltransferase; Female; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Retina; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.}}, language = {{eng}}, month = {{06}}, number = {{8}}, pages = {{802--1799}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{NeuroReport}}, title = {{Correlations between cholinergic neurons and muscarinic m2 receptors in the rat retina}}, volume = {{9}}, year = {{1998}}, }