Physicochemical and drug delivery aspects of lipid-based liquid crystalline nanoparticles: A case study of intravenously administered propofol
(2006) In Journal of Nanoscience and Nanotechnology 6(9-10). p.3017-3024- Abstract
- Liquid crystalline nanoparticles (LCNP) formed through lipid self-assembly have a range of attractive properties as in vivo drug delivery carriers. In particular they offer: a wide solubilization spectrum, and consequently high drug payloads; effective encapsulation; stabilization and protection of sensitive drug substances. Here we present basic physicochemical features of non-lamellar LCNP systems with a focus on intravenous drug applications. This is exemplified by the formulation properties and in vivo behavior using the drug substance propofol; a well-known anesthetic agent currently used in clinical practice in the form of a stable emulsion. In order to appraise the drug delivery features of the LCNP system the current study was... (More)
- Liquid crystalline nanoparticles (LCNP) formed through lipid self-assembly have a range of attractive properties as in vivo drug delivery carriers. In particular they offer: a wide solubilization spectrum, and consequently high drug payloads; effective encapsulation; stabilization and protection of sensitive drug substances. Here we present basic physicochemical features of non-lamellar LCNP systems with a focus on intravenous drug applications. This is exemplified by the formulation properties and in vivo behavior using the drug substance propofol; a well-known anesthetic agent currently used in clinical practice in the form of a stable emulsion. In order to appraise the drug delivery features of the LCNP system the current study was carried out with a marketed propofol emulsion product as reference. In this comparison the propofol-LCNP formulation shows several useful features including: higher drug-loading capacity, lower fat-load, excellent stability, modified pharmacokinetics, and an indication of increased effect duration. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/389512
- author
- Johnsson, Markus LU ; Barauskas, Justas LU ; Norlin, Andreas and Tiberg, Fredrik LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- drug delivery, emulsion, Cubosome (R), nanoparticle, liquid crystal, intravenous, injection, propofol, anesthesia
- in
- Journal of Nanoscience and Nanotechnology
- volume
- 6
- issue
- 9-10
- pages
- 3017 - 3024
- publisher
- American Scientific Publishers
- external identifiers
-
- wos:000240865900046
- scopus:33750058273
- ISSN
- 1533-4880
- DOI
- 10.1166/jnn.2006.402
- language
- English
- LU publication?
- yes
- id
- f85c89c9-a5a4-4baa-8fd2-1a8a9ab28237 (old id 389512)
- date added to LUP
- 2016-04-01 12:25:27
- date last changed
- 2022-01-27 03:32:58
@article{f85c89c9-a5a4-4baa-8fd2-1a8a9ab28237,
abstract = {{Liquid crystalline nanoparticles (LCNP) formed through lipid self-assembly have a range of attractive properties as in vivo drug delivery carriers. In particular they offer: a wide solubilization spectrum, and consequently high drug payloads; effective encapsulation; stabilization and protection of sensitive drug substances. Here we present basic physicochemical features of non-lamellar LCNP systems with a focus on intravenous drug applications. This is exemplified by the formulation properties and in vivo behavior using the drug substance propofol; a well-known anesthetic agent currently used in clinical practice in the form of a stable emulsion. In order to appraise the drug delivery features of the LCNP system the current study was carried out with a marketed propofol emulsion product as reference. In this comparison the propofol-LCNP formulation shows several useful features including: higher drug-loading capacity, lower fat-load, excellent stability, modified pharmacokinetics, and an indication of increased effect duration.}},
author = {{Johnsson, Markus and Barauskas, Justas and Norlin, Andreas and Tiberg, Fredrik}},
issn = {{1533-4880}},
keywords = {{drug delivery; emulsion; Cubosome (R); nanoparticle; liquid crystal; intravenous; injection; propofol; anesthesia}},
language = {{eng}},
number = {{9-10}},
pages = {{3017--3024}},
publisher = {{American Scientific Publishers}},
series = {{Journal of Nanoscience and Nanotechnology}},
title = {{Physicochemical and drug delivery aspects of lipid-based liquid crystalline nanoparticles: A case study of intravenously administered propofol}},
url = {{http://dx.doi.org/10.1166/jnn.2006.402}},
doi = {{10.1166/jnn.2006.402}},
volume = {{6}},
year = {{2006}},
}