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Reliability and construct validity of the compatible MRI scoring system for evaluation of haemophilic knees and ankles of haemophilic children. Expert MRI working group of the international prophylaxis study group

Doria, A. S. ; Babyn, P. S. ; Lundin, Björn LU ; Kilcoyne, R. F. ; Miller, S. ; Rivard, G. E. ; Moineddin, R. and Pettersson, Holger LU (2006) In Haemophilia 12(5). p.503-513
Abstract
We tested the reliability and construct validity of the Compatible magnetic resonance imaging (MRI) scale for the evaluation of haemophilic knees and ankles and compared the diagnostic performance of MRI and plain film radiographs. Sagittal and coronal gradient-echo 1.5-T MR images of knees (n = 22) and ankles (n = 23) were obtained from boys (age range 4-16 years; mean 11 years) in two centres (Toronto, n = 26; Europe, n = 19). The MR images were independently read by four blinded radiologists on two occasions. Number of previous joint bleedings and laboratory level of severity of haemophilia were the reference standards for imaging assessment. Both components of the MRI scale demonstrated high inter- and intrareader intraclass... (More)
We tested the reliability and construct validity of the Compatible magnetic resonance imaging (MRI) scale for the evaluation of haemophilic knees and ankles and compared the diagnostic performance of MRI and plain film radiographs. Sagittal and coronal gradient-echo 1.5-T MR images of knees (n = 22) and ankles (n = 23) were obtained from boys (age range 4-16 years; mean 11 years) in two centres (Toronto, n = 26; Europe, n = 19). The MR images were independently read by four blinded radiologists on two occasions. Number of previous joint bleedings and laboratory level of severity of haemophilia were the reference standards for imaging assessment. Both components of the MRI scale demonstrated high inter- and intrareader intraclass correlation coefficients (progressive (P) scale, 0.91 and 0.94; additive (A) scale, 0.81 and 0.92 respectively). The correlation between the osteochondral domain of the MRI scale and patient's age was moderate. Otherwise, correlations between A- and P-scales and clinical laboratory measurements were weak. The areas under the curve (AUCs) used for discrimination of disease severity were similar for the A- and P-scales (AUCs used for mild disease, A-scale, 0.72 +/- 0.07; P-scale, 0.69 +/- 0.08; P = 0.23; AUCs for severe disease, A-scale, 0.93 +/- 0.05; P-scale, 0.87 +/- 0.08; P = 0.05). No differences were noted between the AUCs of the MRI and radiographic scales used for discrimination of late osteoarticular changes; MRI scales performed better for discrimination of early changes. In conclusion, both MRI scales demonstrated excellent reliability, poor convergent validity, and moderate and excellent validity for discrimination of mild and severe diseases respectively. Compared with radiographic scores, the MRI scales performed better for discrimination of early osteoarticular changes. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
haemophilia, discriminant validity, arthropathy, children, systems, MRI scoring, reliability
in
Haemophilia
volume
12
issue
5
pages
503 - 513
publisher
Wiley-Blackwell
external identifiers
  • wos:000239779600007
  • scopus:33747180131
ISSN
1351-8216
DOI
10.1111/j.1365-2516.2006.01310.x
language
English
LU publication?
yes
id
6e5390e8-289b-4a4f-b6d5-379f0d23aa99 (old id 397440)
date added to LUP
2016-04-01 11:52:55
date last changed
2022-02-03 06:30:06
@article{6e5390e8-289b-4a4f-b6d5-379f0d23aa99,
  abstract     = {{We tested the reliability and construct validity of the Compatible magnetic resonance imaging (MRI) scale for the evaluation of haemophilic knees and ankles and compared the diagnostic performance of MRI and plain film radiographs. Sagittal and coronal gradient-echo 1.5-T MR images of knees (n = 22) and ankles (n = 23) were obtained from boys (age range 4-16 years; mean 11 years) in two centres (Toronto, n = 26; Europe, n = 19). The MR images were independently read by four blinded radiologists on two occasions. Number of previous joint bleedings and laboratory level of severity of haemophilia were the reference standards for imaging assessment. Both components of the MRI scale demonstrated high inter- and intrareader intraclass correlation coefficients (progressive (P) scale, 0.91 and 0.94; additive (A) scale, 0.81 and 0.92 respectively). The correlation between the osteochondral domain of the MRI scale and patient's age was moderate. Otherwise, correlations between A- and P-scales and clinical laboratory measurements were weak. The areas under the curve (AUCs) used for discrimination of disease severity were similar for the A- and P-scales (AUCs used for mild disease, A-scale, 0.72 +/- 0.07; P-scale, 0.69 +/- 0.08; P = 0.23; AUCs for severe disease, A-scale, 0.93 +/- 0.05; P-scale, 0.87 +/- 0.08; P = 0.05). No differences were noted between the AUCs of the MRI and radiographic scales used for discrimination of late osteoarticular changes; MRI scales performed better for discrimination of early changes. In conclusion, both MRI scales demonstrated excellent reliability, poor convergent validity, and moderate and excellent validity for discrimination of mild and severe diseases respectively. Compared with radiographic scores, the MRI scales performed better for discrimination of early osteoarticular changes.}},
  author       = {{Doria, A. S. and Babyn, P. S. and Lundin, Björn and Kilcoyne, R. F. and Miller, S. and Rivard, G. E. and Moineddin, R. and Pettersson, Holger}},
  issn         = {{1351-8216}},
  keywords     = {{haemophilia; discriminant validity; arthropathy; children; systems; MRI scoring; reliability}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{503--513}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Haemophilia}},
  title        = {{Reliability and construct validity of the compatible MRI scoring system for evaluation of haemophilic knees and ankles of haemophilic children. Expert MRI working group of the international prophylaxis study group}},
  url          = {{http://dx.doi.org/10.1111/j.1365-2516.2006.01310.x}},
  doi          = {{10.1111/j.1365-2516.2006.01310.x}},
  volume       = {{12}},
  year         = {{2006}},
}