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Comorbidities in osteoarthritis (ComOA) : a combined cross-sectional, case-control and cohort study using large electronic health records in four European countries

Swain, Subhashisa ; Kamps, Anne ; Runhaar, Jos ; Dell'isola, Andrea LU ; Turkiewicz, Aleksandra LU ; Robinson, Danielle ; Strauss, V. ; Mallen, Christian ; Kuo, Chang Fu and Coupland, Carol , et al. (2022) In BMJ Open 12(4).
Abstract

Introduction Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the comorbidities, role of analgesics and the causality and variation between populations are yet to be investigated. This paper describes the protocol of a multinational study in four European countries (UK, Netherlands, Sweden and Spain) exploring comorbidities in people with OA. Methods and analysis This multinational study will investigate (1) the temporal associations of 61 identified comorbidities with OA, (2) the clusters and trajectories of comorbidities in people with OA, (3) the role of... (More)

Introduction Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the comorbidities, role of analgesics and the causality and variation between populations are yet to be investigated. This paper describes the protocol of a multinational study in four European countries (UK, Netherlands, Sweden and Spain) exploring comorbidities in people with OA. Methods and analysis This multinational study will investigate (1) the temporal associations of 61 identified comorbidities with OA, (2) the clusters and trajectories of comorbidities in people with OA, (3) the role of analgesics on incidence of comorbidities in people with OA, (4) the potential biomarkers and causality between OA and the comorbidities, and (5) variations between countries. A combined case-control and cohort study will be conducted to find the temporal association of OA with the comorbidities using the national or regional health databases. Latent class analysis will be performed to identify the clusters at baseline and joint latent class analysis will be used to examine trajectories during the follow-up. A cohort study will be undertaken to evaluate the role of non-steroidal anti-inflammatory drugs (NSAIDs), opioids and paracetamol on the incidence of comorbidities. Mendelian randomisation will be performed to investigate the potential biomarkers for causality between OA and the comorbidities using the UK Biobank and the Rotterdam Study databases. Finally, a meta-analyses will be used to examine the variations and pool the results from different countries. Ethics and dissemination Research ethics was obtained according to each database requirement. Results will be disseminated through the FOREUM website, scientific meetings, publications and in partnership with patient organisations.

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type
Contribution to journal
publication status
published
subject
keywords
EPIDEMIOLOGY, Musculoskeletal disorders, RHEUMATOLOGY
in
BMJ Open
volume
12
issue
4
article number
e052816
publisher
BMJ Publishing Group
external identifiers
  • scopus:85127621323
  • pmid:35387809
ISSN
2044-6055
DOI
10.1136/bmjopen-2021-052816
language
English
LU publication?
yes
id
3a711ba1-fb0a-41ec-ab03-5a655687567b
date added to LUP
2022-06-09 11:18:14
date last changed
2024-09-20 00:54:43
@article{3a711ba1-fb0a-41ec-ab03-5a655687567b,
  abstract     = {{<p>Introduction Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the comorbidities, role of analgesics and the causality and variation between populations are yet to be investigated. This paper describes the protocol of a multinational study in four European countries (UK, Netherlands, Sweden and Spain) exploring comorbidities in people with OA. Methods and analysis This multinational study will investigate (1) the temporal associations of 61 identified comorbidities with OA, (2) the clusters and trajectories of comorbidities in people with OA, (3) the role of analgesics on incidence of comorbidities in people with OA, (4) the potential biomarkers and causality between OA and the comorbidities, and (5) variations between countries. A combined case-control and cohort study will be conducted to find the temporal association of OA with the comorbidities using the national or regional health databases. Latent class analysis will be performed to identify the clusters at baseline and joint latent class analysis will be used to examine trajectories during the follow-up. A cohort study will be undertaken to evaluate the role of non-steroidal anti-inflammatory drugs (NSAIDs), opioids and paracetamol on the incidence of comorbidities. Mendelian randomisation will be performed to investigate the potential biomarkers for causality between OA and the comorbidities using the UK Biobank and the Rotterdam Study databases. Finally, a meta-analyses will be used to examine the variations and pool the results from different countries. Ethics and dissemination Research ethics was obtained according to each database requirement. Results will be disseminated through the FOREUM website, scientific meetings, publications and in partnership with patient organisations. </p>}},
  author       = {{Swain, Subhashisa and Kamps, Anne and Runhaar, Jos and Dell'isola, Andrea and Turkiewicz, Aleksandra and Robinson, Danielle and Strauss, V. and Mallen, Christian and Kuo, Chang Fu and Coupland, Carol and Doherty, Michael and Sarmanova, Aliya and Prieto-Alhambra, Daniel and Englund, Martin and Bierma-Zeinstra, Sita M.A. and Zhang, Weiya}},
  issn         = {{2044-6055}},
  keywords     = {{EPIDEMIOLOGY; Musculoskeletal disorders; RHEUMATOLOGY}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open}},
  title        = {{Comorbidities in osteoarthritis (ComOA) : a combined cross-sectional, case-control and cohort study using large electronic health records in four European countries}},
  url          = {{http://dx.doi.org/10.1136/bmjopen-2021-052816}},
  doi          = {{10.1136/bmjopen-2021-052816}},
  volume       = {{12}},
  year         = {{2022}},
}