Regulation of unfolded protein response in hematopoietic stem cells
(2018) In International Journal of Hematology 107(6). p.627-633- Abstract
Hematopoietic stem cells (HSCs) play a central role in hematopoietic regeneration, which has been demonstrated by thorough studies. In contrast, the cell cycle status and metabolic condition of HSCs define these cells as dormant. Recent studies have also revealed that protein metabolism is quite unique, as dormant HSCs have a lower protein synthesis rate and folding capacity. Under proliferative conditions, upon hematopoietic stress, HSCs need to deal with higher requirements of protein production to achieve fast and effective blood replenishment. In such cases, increased protein synthesis could exceed the capacity of precise protein quality control, leading to the accumulation of unfolded and misfolded proteins. In turn, this triggers... (More)
Hematopoietic stem cells (HSCs) play a central role in hematopoietic regeneration, which has been demonstrated by thorough studies. In contrast, the cell cycle status and metabolic condition of HSCs define these cells as dormant. Recent studies have also revealed that protein metabolism is quite unique, as dormant HSCs have a lower protein synthesis rate and folding capacity. Under proliferative conditions, upon hematopoietic stress, HSCs need to deal with higher requirements of protein production to achieve fast and effective blood replenishment. In such cases, increased protein synthesis could exceed the capacity of precise protein quality control, leading to the accumulation of unfolded and misfolded proteins. In turn, this triggers endoplasmic reticulum (ER) stress as a part of the unfolded protein response (UPR). Since ER stress is a multi-layered, bidirectional cellular response that contains both positive (survival) and negative (death) reactions, proper management of UPR and ER stress signals is crucial for HSCs and also for maintaining the healthy hematopoietic system. In this review, we introduce the latest findings in this emerging field within hematopoiesis and HSC regulation.
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- author
- Sigurdsson, Valgardur LU and Miharada, Kenichi LU
- organization
- publishing date
- 2018-05-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bile acid, ER stress, Hematopoietic stem cell, Proteostasis, Unfolded protein response
- in
- International Journal of Hematology
- volume
- 107
- issue
- 6
- pages
- 627 - 633
- publisher
- Springer
- external identifiers
-
- pmid:29725845
- scopus:85046404673
- ISSN
- 0925-5710
- DOI
- 10.1007/s12185-018-2458-7
- language
- English
- LU publication?
- yes
- id
- 3d88fe99-14dd-4d71-bb84-4e161d561fe9
- date added to LUP
- 2018-05-15 12:22:51
- date last changed
- 2024-11-12 05:13:35
@article{3d88fe99-14dd-4d71-bb84-4e161d561fe9,
abstract = {{<p>Hematopoietic stem cells (HSCs) play a central role in hematopoietic regeneration, which has been demonstrated by thorough studies. In contrast, the cell cycle status and metabolic condition of HSCs define these cells as dormant. Recent studies have also revealed that protein metabolism is quite unique, as dormant HSCs have a lower protein synthesis rate and folding capacity. Under proliferative conditions, upon hematopoietic stress, HSCs need to deal with higher requirements of protein production to achieve fast and effective blood replenishment. In such cases, increased protein synthesis could exceed the capacity of precise protein quality control, leading to the accumulation of unfolded and misfolded proteins. In turn, this triggers endoplasmic reticulum (ER) stress as a part of the unfolded protein response (UPR). Since ER stress is a multi-layered, bidirectional cellular response that contains both positive (survival) and negative (death) reactions, proper management of UPR and ER stress signals is crucial for HSCs and also for maintaining the healthy hematopoietic system. In this review, we introduce the latest findings in this emerging field within hematopoiesis and HSC regulation.</p>}},
author = {{Sigurdsson, Valgardur and Miharada, Kenichi}},
issn = {{0925-5710}},
keywords = {{Bile acid; ER stress; Hematopoietic stem cell; Proteostasis; Unfolded protein response}},
language = {{eng}},
month = {{05}},
number = {{6}},
pages = {{627--633}},
publisher = {{Springer}},
series = {{International Journal of Hematology}},
title = {{Regulation of unfolded protein response in hematopoietic stem cells}},
url = {{http://dx.doi.org/10.1007/s12185-018-2458-7}},
doi = {{10.1007/s12185-018-2458-7}},
volume = {{107}},
year = {{2018}},
}