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Modulation of the gut microbiome with nisin

O’Reilly, Catherine ; Grimaud, Ghjuvan M. LU orcid ; Coakley, Mairéad ; O’Connor, Paula M. ; Mathur, Harsh ; Peterson, Veronica L. ; O’Donovan, Ciara M. ; Lawlor, Peadar G. ; Cotter, Paul D. and Stanton, Catherine , et al. (2023) In Scientific Reports 13(1).
Abstract

Nisin is a broad spectrum bacteriocin used extensively as a food preservative that was identified in Lactococcus lactis nearly a century ago. We show that orally-ingested nisin survives transit through the porcine gastrointestinal tract intact (as evidenced by activity and molecular weight determination) where it impacts both the composition and functioning of the microbiota. Specifically, nisin treatment caused a reversible decrease in Gram positive bacteria, resulting in a reshaping of the Firmicutes and a corresponding relative increase in Gram negative Proteobacteria. These changes were mirrored by the modification in relative abundance of pathways involved in acetate, butyrate (decreased) and propionate (increased) synthesis which... (More)

Nisin is a broad spectrum bacteriocin used extensively as a food preservative that was identified in Lactococcus lactis nearly a century ago. We show that orally-ingested nisin survives transit through the porcine gastrointestinal tract intact (as evidenced by activity and molecular weight determination) where it impacts both the composition and functioning of the microbiota. Specifically, nisin treatment caused a reversible decrease in Gram positive bacteria, resulting in a reshaping of the Firmicutes and a corresponding relative increase in Gram negative Proteobacteria. These changes were mirrored by the modification in relative abundance of pathways involved in acetate, butyrate (decreased) and propionate (increased) synthesis which correlated with overall reductions in short chain fatty acid levels in stool. These reversible changes that occur as a result of nisin ingestion demonstrate the potential of bacteriocins like nisin to shape mammalian microbiomes and impact on the functionality of the community.

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publishing date
type
Contribution to journal
publication status
published
in
Scientific Reports
volume
13
issue
1
article number
7899
publisher
Nature Publishing Group
external identifiers
  • scopus:85159491574
  • pmid:37193715
ISSN
2045-2322
DOI
10.1038/s41598-023-34586-x
language
English
LU publication?
no
additional info
Publisher Copyright: © 2023, The Author(s).
id
3e021f46-19a4-4354-b736-0f4a47accb57
date added to LUP
2024-11-25 16:10:19
date last changed
2025-07-08 10:32:13
@article{3e021f46-19a4-4354-b736-0f4a47accb57,
  abstract     = {{<p>Nisin is a broad spectrum bacteriocin used extensively as a food preservative that was identified in Lactococcus lactis nearly a century ago. We show that orally-ingested nisin survives transit through the porcine gastrointestinal tract intact (as evidenced by activity and molecular weight determination) where it impacts both the composition and functioning of the microbiota. Specifically, nisin treatment caused a reversible decrease in Gram positive bacteria, resulting in a reshaping of the Firmicutes and a corresponding relative increase in Gram negative Proteobacteria. These changes were mirrored by the modification in relative abundance of pathways involved in acetate, butyrate (decreased) and propionate (increased) synthesis which correlated with overall reductions in short chain fatty acid levels in stool. These reversible changes that occur as a result of nisin ingestion demonstrate the potential of bacteriocins like nisin to shape mammalian microbiomes and impact on the functionality of the community.</p>}},
  author       = {{O’Reilly, Catherine and Grimaud, Ghjuvan M. and Coakley, Mairéad and O’Connor, Paula M. and Mathur, Harsh and Peterson, Veronica L. and O’Donovan, Ciara M. and Lawlor, Peadar G. and Cotter, Paul D. and Stanton, Catherine and Rea, Mary C. and Hill, Colin and Ross, R. Paul}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Modulation of the gut microbiome with nisin}},
  url          = {{http://dx.doi.org/10.1038/s41598-023-34586-x}},
  doi          = {{10.1038/s41598-023-34586-x}},
  volume       = {{13}},
  year         = {{2023}},
}