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Long-term safety of Gadofosveset in clinical practice

Åkesson, Michael LU ; Lehti, Leena LU ; Leander, Peter LU ; Sterner, Gunnar LU and Wassélius, Johan LU (2022) In Magnetic Resonance Imaging 86. p.70-73
Abstract

Purpose: The purpose of this study was to systematically search for long-term complications, including Nephrogenic Systemic Fibrosis (NSF), in patients who were previously administered the gadolinium-based contrast agent Gadofosveset at our institute. Materials and methods: All patients who were administered Gadofosveset at our institute between 2006 and 2009 were identified in our Radiological Information System (RIS). Clinical data such as cause of death during follow-up, and dermatological or nephrological diseases were systematically searched for in electronic patient records (EPR). Results: During 2006–2009, Gadofosveset was administered a total of 67 times to 62 patients. One patient was unavailable for follow-up. The remaining 61... (More)

Purpose: The purpose of this study was to systematically search for long-term complications, including Nephrogenic Systemic Fibrosis (NSF), in patients who were previously administered the gadolinium-based contrast agent Gadofosveset at our institute. Materials and methods: All patients who were administered Gadofosveset at our institute between 2006 and 2009 were identified in our Radiological Information System (RIS). Clinical data such as cause of death during follow-up, and dermatological or nephrological diseases were systematically searched for in electronic patient records (EPR). Results: During 2006–2009, Gadofosveset was administered a total of 67 times to 62 patients. One patient was unavailable for follow-up. The remaining 61 patients were followed up for up to 14 (median 12) years based on RIS and EPR data. There were 13 deaths among the 61 patients, all assessed as unrelated to Gadofosveset administration. No dermatological or renal disease suggestive of NSF, or potentially related to Gadofosveset administration, was found. At the time of examination, six patients were diagnosed with various stages of renal insufficiency, three of whom were on hemodialysis. Another three patients were diagnosed with renal insufficiency during the follow-up period, but none of these diagnoses were suspected to be related to the administration of Gadofosveset. Conclusions: Based on the results of this retrospective safety analysis of up to 14 years following 1–2 exposures, we conclude that Gadofosveset in clinical practice is safe in the long-term.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood pool contrast medium, Gadofosveset, Gadolinium based contrast agent (GBCA), Magnetic resonance imaging, Nephrogenic systemic fibrosis
in
Magnetic Resonance Imaging
volume
86
pages
4 pages
publisher
Elsevier
external identifiers
  • pmid:34848324
  • scopus:85120169323
ISSN
0730-725X
DOI
10.1016/j.mri.2021.11.011
language
English
LU publication?
yes
id
3f850499-ca6a-4f30-99db-b028ec18b4e4
date added to LUP
2021-12-15 10:33:37
date last changed
2024-06-15 22:43:34
@article{3f850499-ca6a-4f30-99db-b028ec18b4e4,
  abstract     = {{<p>Purpose: The purpose of this study was to systematically search for long-term complications, including Nephrogenic Systemic Fibrosis (NSF), in patients who were previously administered the gadolinium-based contrast agent Gadofosveset at our institute. Materials and methods: All patients who were administered Gadofosveset at our institute between 2006 and 2009 were identified in our Radiological Information System (RIS). Clinical data such as cause of death during follow-up, and dermatological or nephrological diseases were systematically searched for in electronic patient records (EPR). Results: During 2006–2009, Gadofosveset was administered a total of 67 times to 62 patients. One patient was unavailable for follow-up. The remaining 61 patients were followed up for up to 14 (median 12) years based on RIS and EPR data. There were 13 deaths among the 61 patients, all assessed as unrelated to Gadofosveset administration. No dermatological or renal disease suggestive of NSF, or potentially related to Gadofosveset administration, was found. At the time of examination, six patients were diagnosed with various stages of renal insufficiency, three of whom were on hemodialysis. Another three patients were diagnosed with renal insufficiency during the follow-up period, but none of these diagnoses were suspected to be related to the administration of Gadofosveset. Conclusions: Based on the results of this retrospective safety analysis of up to 14 years following 1–2 exposures, we conclude that Gadofosveset in clinical practice is safe in the long-term.</p>}},
  author       = {{Åkesson, Michael and Lehti, Leena and Leander, Peter and Sterner, Gunnar and Wassélius, Johan}},
  issn         = {{0730-725X}},
  keywords     = {{Blood pool contrast medium; Gadofosveset; Gadolinium based contrast agent (GBCA); Magnetic resonance imaging; Nephrogenic systemic fibrosis}},
  language     = {{eng}},
  pages        = {{70--73}},
  publisher    = {{Elsevier}},
  series       = {{Magnetic Resonance Imaging}},
  title        = {{Long-term safety of Gadofosveset in clinical practice}},
  url          = {{http://dx.doi.org/10.1016/j.mri.2021.11.011}},
  doi          = {{10.1016/j.mri.2021.11.011}},
  volume       = {{86}},
  year         = {{2022}},
}