''Sponge" nanoparticle dispersions in aqueous mixtures of diglycerol monooleate, glycerol dioleate, and polysorbate 80
(2006) In Langmuir 22(14). p.6328-6334- Abstract
- Lipid nanoparticles of nonlamellar lyotropic phases have a wide solubilizing and encapsulating spectrum for a range of substances thanks to their nanostructured interior featuring both lipophilic and hydrophilic domains. As a consequence, these systems have emerged as promising drug delivery systems in various pharmaceutical and diagnostic applications. Here we present the phase behavior and dispersion properties of a novel three-component lipid system composed of diglycerol monooleate (DGMO), glycerol dioleate (GDO), and polysorbate 80 (P80) which shows several advantageous features relating to drug delivery applications including: spontaneous dispersion formation with a narrow size distribution and tunable particle phase-structure. The... (More)
- Lipid nanoparticles of nonlamellar lyotropic phases have a wide solubilizing and encapsulating spectrum for a range of substances thanks to their nanostructured interior featuring both lipophilic and hydrophilic domains. As a consequence, these systems have emerged as promising drug delivery systems in various pharmaceutical and diagnostic applications. Here we present the phase behavior and dispersion properties of a novel three-component lipid system composed of diglycerol monooleate (DGMO), glycerol dioleate (GDO), and polysorbate 80 (P80) which shows several advantageous features relating to drug delivery applications including: spontaneous dispersion formation with a narrow size distribution and tunable particle phase-structure. The obtained phase diagram shows the presence of lamellar (L-alpha), hexagonal (H-2), and reverse bicontinuous cubic (V-2) liquid crystalline phases and an inverse micellar (L-2) solution. A particularly interesting observation is the presence of a phase region where two liquid phases coexist, most likely the L-2 and L-3 ("sponge phase"). These two phase structures appear also to coexist in the submicron particles formed in the dilute water region, where the L-3 element appears to stabilize nanoparticles with inner L-2 structure. Increasing the fraction of the dispersing P80 component results in the growth of the more water rich L-3 "surface phase" at the expense of the size of the inner L-2 core. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/404831
- author
- Barauskas, Justas LU ; Misiunas, Audrius LU ; Gunnarsson, Torsten ; Tiberg, Fredrik LU and Johnsson, Markus LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Langmuir
- volume
- 22
- issue
- 14
- pages
- 6328 - 6334
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000238558500051
- scopus:33746550283
- ISSN
- 0743-7463
- DOI
- 10.1021/la060295f
- language
- English
- LU publication?
- yes
- id
- 585b006b-76dd-425a-9c29-cb5712a33152 (old id 404831)
- date added to LUP
- 2016-04-01 12:32:03
- date last changed
- 2022-01-27 06:22:01
@article{585b006b-76dd-425a-9c29-cb5712a33152,
abstract = {{Lipid nanoparticles of nonlamellar lyotropic phases have a wide solubilizing and encapsulating spectrum for a range of substances thanks to their nanostructured interior featuring both lipophilic and hydrophilic domains. As a consequence, these systems have emerged as promising drug delivery systems in various pharmaceutical and diagnostic applications. Here we present the phase behavior and dispersion properties of a novel three-component lipid system composed of diglycerol monooleate (DGMO), glycerol dioleate (GDO), and polysorbate 80 (P80) which shows several advantageous features relating to drug delivery applications including: spontaneous dispersion formation with a narrow size distribution and tunable particle phase-structure. The obtained phase diagram shows the presence of lamellar (L-alpha), hexagonal (H-2), and reverse bicontinuous cubic (V-2) liquid crystalline phases and an inverse micellar (L-2) solution. A particularly interesting observation is the presence of a phase region where two liquid phases coexist, most likely the L-2 and L-3 ("sponge phase"). These two phase structures appear also to coexist in the submicron particles formed in the dilute water region, where the L-3 element appears to stabilize nanoparticles with inner L-2 structure. Increasing the fraction of the dispersing P80 component results in the growth of the more water rich L-3 "surface phase" at the expense of the size of the inner L-2 core.}},
author = {{Barauskas, Justas and Misiunas, Audrius and Gunnarsson, Torsten and Tiberg, Fredrik and Johnsson, Markus}},
issn = {{0743-7463}},
language = {{eng}},
number = {{14}},
pages = {{6328--6334}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Langmuir}},
title = {{''Sponge" nanoparticle dispersions in aqueous mixtures of diglycerol monooleate, glycerol dioleate, and polysorbate 80}},
url = {{http://dx.doi.org/10.1021/la060295f}},
doi = {{10.1021/la060295f}},
volume = {{22}},
year = {{2006}},
}