Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

The basement membrane in the cross-roads between the lung and kidney

Jandl, Katharina ; Mutgan, Ayse Ceren LU orcid ; Eller, Kathrin ; Schaefer, Liliana and Kwapiszewska, Grazyna (2022) In Matrix Biology 105. p.31-52
Abstract

The basement membrane (BM) is a specialized layer of extracellular matrix components that plays a central role in maintaining lung and kidney functions. Although the composition of the BM is usually tissue specific, the lung and the kidney preferentially use similar BM components. Unsurprisingly, diseases with BM defects often have severe pulmonary or renal manifestations, sometimes both. Excessive remodeling of the BM, which is a hallmark of both inflammatory and fibrosing diseases in the lung and the kidney, can lead to the release of BM-derived matrikines, proteolytic fragments with distinct biological functions. These matrikines can then influence disease activity at the site of liberation. However, they are also released to the... (More)

The basement membrane (BM) is a specialized layer of extracellular matrix components that plays a central role in maintaining lung and kidney functions. Although the composition of the BM is usually tissue specific, the lung and the kidney preferentially use similar BM components. Unsurprisingly, diseases with BM defects often have severe pulmonary or renal manifestations, sometimes both. Excessive remodeling of the BM, which is a hallmark of both inflammatory and fibrosing diseases in the lung and the kidney, can lead to the release of BM-derived matrikines, proteolytic fragments with distinct biological functions. These matrikines can then influence disease activity at the site of liberation. However, they are also released to the circulation, where they can directly affect the vascular endothelium or target other organs, leading to extrapulmonary or extrarenal manifestations. In this review, we will summarize the current knowledge of the composition and function of the BM and its matrikines in health and disease, both in the lung and in the kidney. By comparison, we will highlight, why the BM and its matrikines may be central in establishing a renal-pulmonary interaction axis.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Endostatin, Extracellular matrix, Inflammation, Matrikines, Toll-like receptor, Type IV collagen
in
Matrix Biology
volume
105
pages
31 - 52
publisher
Elsevier
external identifiers
  • pmid:34839001
  • scopus:85120633358
ISSN
0945-053X
DOI
10.1016/j.matbio.2021.11.003
language
English
LU publication?
no
additional info
Publisher Copyright: © 2021 The Authors
id
404d9d12-0d36-4240-833b-e84a4bc4314e
date added to LUP
2025-03-20 13:56:10
date last changed
2025-07-10 22:39:28
@article{404d9d12-0d36-4240-833b-e84a4bc4314e,
  abstract     = {{<p>The basement membrane (BM) is a specialized layer of extracellular matrix components that plays a central role in maintaining lung and kidney functions. Although the composition of the BM is usually tissue specific, the lung and the kidney preferentially use similar BM components. Unsurprisingly, diseases with BM defects often have severe pulmonary or renal manifestations, sometimes both. Excessive remodeling of the BM, which is a hallmark of both inflammatory and fibrosing diseases in the lung and the kidney, can lead to the release of BM-derived matrikines, proteolytic fragments with distinct biological functions. These matrikines can then influence disease activity at the site of liberation. However, they are also released to the circulation, where they can directly affect the vascular endothelium or target other organs, leading to extrapulmonary or extrarenal manifestations. In this review, we will summarize the current knowledge of the composition and function of the BM and its matrikines in health and disease, both in the lung and in the kidney. By comparison, we will highlight, why the BM and its matrikines may be central in establishing a renal-pulmonary interaction axis.</p>}},
  author       = {{Jandl, Katharina and Mutgan, Ayse Ceren and Eller, Kathrin and Schaefer, Liliana and Kwapiszewska, Grazyna}},
  issn         = {{0945-053X}},
  keywords     = {{Endostatin; Extracellular matrix; Inflammation; Matrikines; Toll-like receptor; Type IV collagen}},
  language     = {{eng}},
  pages        = {{31--52}},
  publisher    = {{Elsevier}},
  series       = {{Matrix Biology}},
  title        = {{The basement membrane in the cross-roads between the lung and kidney}},
  url          = {{http://dx.doi.org/10.1016/j.matbio.2021.11.003}},
  doi          = {{10.1016/j.matbio.2021.11.003}},
  volume       = {{105}},
  year         = {{2022}},
}