Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.
(2013) In Cell Stem Cell 13(5). p.535-548- Abstract
- In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to... (More)
- In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis. (Less)
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https://lup.lub.lu.se/record/4065547
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cell Stem Cell
- volume
- 13
- issue
- 5
- pages
- 535 - 548
- publisher
- Cell Press
- external identifiers
-
- wos:000329571500007
- pmid:24054998
- pmid:24054998
- scopus:85027937601
- ISSN
- 1934-5909
- DOI
- 10.1016/j.stem.2013.08.012
- language
- English
- LU publication?
- yes
- id
- 9737163f-4baf-4db0-9ed7-507f53fe30bf (old id 4065547)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24054998?dopt=Abstract
- date added to LUP
- 2016-04-01 10:31:54
- date last changed
- 2022-08-20 03:42:09
@article{9737163f-4baf-4db0-9ed7-507f53fe30bf, abstract = {{In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis.}}, author = {{Böiers, Charlotta and Carrelha, Joana and Lutteropp, Michael and Luc, Sidinh and Green, Joanna C A and Azzoni, Emanuele and Woll, Petter S and Mead, Adam J and Hultquist, Anne and Swiers, Gemma and Perdiguero, Elisa Gomez and Macaulay, Iain C and Melchiori, Luca and Luis, Tiago C and Kharazi, Shabnam and Bouriez-Jones, Tiphaine and Deng, Qiaolin and Pontén, Annica and Atkinson, Deborah and Jensen, Christina and Sitnicka Quinn, Ewa and Geissmann, Frederic and Godin, Isabelle and Sandberg, Rickard and de Bruijn, Marella F T R and Jacobsen, Sten Eirik W}}, issn = {{1934-5909}}, language = {{eng}}, number = {{5}}, pages = {{535--548}}, publisher = {{Cell Press}}, series = {{Cell Stem Cell}}, title = {{Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.}}, url = {{http://dx.doi.org/10.1016/j.stem.2013.08.012}}, doi = {{10.1016/j.stem.2013.08.012}}, volume = {{13}}, year = {{2013}}, }