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Patch Testing in Individuals With Diabetes Using Medical Devices. Part 2—Contact Allergy to Medical Device Allergens and New Patch Test Recommendations

Ulriksdotter, Josefin LU orcid ; Mowitz, Martin LU ; Sukakul, Thanisorn LU orcid ; Bruze, Magnus LU ; Hamnerius, Nils LU and Svedman, Cecilia LU (2026) In Contact Dermatitis
Abstract

Background: Previous studies on contact allergy to diabetes medical devices (MDs) are based on patients referred for patch testing due to suspected allergic contact dermatitis. Objectives: To present real-world data on contact allergy to MD allergens among diabetes MD users. To suggest a MD patch test series. Methods: Adults with type 1 diabetes using diabetes MDs followed up at two endocrinology departments were invited to be patch tested with a novel MD patch test series. Results: Of the 204 participants (114 with skin rash to diabetes MDs, 90 without), 16.2% were positive to allergens found in diabetes MDs. The prevalence was significantly higher in those with skin rash to diabetes MDs versus without (28.1% vs. 1.1%; adjusted p-value... (More)

Background: Previous studies on contact allergy to diabetes medical devices (MDs) are based on patients referred for patch testing due to suspected allergic contact dermatitis. Objectives: To present real-world data on contact allergy to MD allergens among diabetes MD users. To suggest a MD patch test series. Methods: Adults with type 1 diabetes using diabetes MDs followed up at two endocrinology departments were invited to be patch tested with a novel MD patch test series. Results: Of the 204 participants (114 with skin rash to diabetes MDs, 90 without), 16.2% were positive to allergens found in diabetes MDs. The prevalence was significantly higher in those with skin rash to diabetes MDs versus without (28.1% vs. 1.1%; adjusted p-value < 0.001). For allergens found in diabetes MDs, the highest contact allergy rates were seen to isobornyl acrylate (10.3%), N,N-dimethylacrylamide (4.9%), 2-hydroxyethyl acrylate (3.4%), and dicyclohexylmethane-4,4′-diisocyanate (2.9%). Conclusions: Among diabetes MD users, the prevalence of contact allergy to MD allergens was remarkably high. 2-hydroxyethyl acrylate has not previously been reported as a culprit allergen in diabetes MDs, which underlines the importance of repeated chemical analyses and continuous update of the MD series. A better prevention of MD-related contact allergies is called for.

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Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
contact allergy, continuous glucose monitoring, insulin infusion systems, type 1 diabetes
in
Contact Dermatitis
publisher
Wiley-Blackwell
external identifiers
  • pmid:41936552
  • scopus:105034863602
ISSN
0105-1873
DOI
10.1111/cod.70149
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2026 The Author(s). Contact Dermatitis published by John Wiley & Sons Ltd.
id
41afe453-61f2-46a8-9009-1e145bccb391
date added to LUP
2026-06-18 10:10:17
date last changed
2026-06-19 03:18:21
@article{41afe453-61f2-46a8-9009-1e145bccb391,
  abstract     = {{<p>Background: Previous studies on contact allergy to diabetes medical devices (MDs) are based on patients referred for patch testing due to suspected allergic contact dermatitis. Objectives: To present real-world data on contact allergy to MD allergens among diabetes MD users. To suggest a MD patch test series. Methods: Adults with type 1 diabetes using diabetes MDs followed up at two endocrinology departments were invited to be patch tested with a novel MD patch test series. Results: Of the 204 participants (114 with skin rash to diabetes MDs, 90 without), 16.2% were positive to allergens found in diabetes MDs. The prevalence was significantly higher in those with skin rash to diabetes MDs versus without (28.1% vs. 1.1%; adjusted p-value &lt; 0.001). For allergens found in diabetes MDs, the highest contact allergy rates were seen to isobornyl acrylate (10.3%), N,N-dimethylacrylamide (4.9%), 2-hydroxyethyl acrylate (3.4%), and dicyclohexylmethane-4,4′-diisocyanate (2.9%). Conclusions: Among diabetes MD users, the prevalence of contact allergy to MD allergens was remarkably high. 2-hydroxyethyl acrylate has not previously been reported as a culprit allergen in diabetes MDs, which underlines the importance of repeated chemical analyses and continuous update of the MD series. A better prevention of MD-related contact allergies is called for.</p>}},
  author       = {{Ulriksdotter, Josefin and Mowitz, Martin and Sukakul, Thanisorn and Bruze, Magnus and Hamnerius, Nils and Svedman, Cecilia}},
  issn         = {{0105-1873}},
  keywords     = {{contact allergy; continuous glucose monitoring; insulin infusion systems; type 1 diabetes}},
  language     = {{eng}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Patch Testing in Individuals With Diabetes Using Medical Devices. Part 2—Contact Allergy to Medical Device Allergens and New Patch Test Recommendations}},
  url          = {{http://dx.doi.org/10.1111/cod.70149}},
  doi          = {{10.1111/cod.70149}},
  year         = {{2026}},
}