Sex bias in FGFR3 somatic mutations in bladder cancer
Meng, Xiangyu and Wang, Qiaoli LU
(2024)
In Oncology and Translational Medicine
10(5).
p.252-256
- Abstract
Background: Strong sex disparities have been observed among patients with bladder cancer (BCa). FGFR3 is one of the most frequently mutated genes in bladder cancer, and there are inconsistencies in its frequency in male and female patients. Methods: Here, we conducted a meta-analysis comparing the FGFR3 somatic mutation frequency in men and women among 7351 patients with BCa from 18 cohorts. Results: We showed that female patients had a 1.32 times higher risk of having FGFR3 somatic mutations than males. This difference was attributed to mutations occurring at the 2 most frequently mutated sites, S249 and Y375. Additionally, nonsense mutations were more likely to be found in women, whereas indel/frameshift mutations were almost... (More)
Background: Strong sex disparities have been observed among patients with bladder cancer (BCa). FGFR3 is one of the most frequently mutated genes in bladder cancer, and there are inconsistencies in its frequency in male and female patients. Methods: Here, we conducted a meta-analysis comparing the FGFR3 somatic mutation frequency in men and women among 7351 patients with BCa from 18 cohorts. Results: We showed that female patients had a 1.32 times higher risk of having FGFR3 somatic mutations than males. This difference was attributed to mutations occurring at the 2 most frequently mutated sites, S249 and Y375. Additionally, nonsense mutations were more likely to be found in women, whereas indel/frameshift mutations were almost exclusively found in men; however, no difference was noted for missense mutations. Conclusions: A female sex bias in FGFR3 somatic mutations was observed in BCa. Well-powered individual participant data analyses addressing the possible confounding effects of other factors (eg, age, ethnicity, smoking status, muscle invasiveness, and molecular subtype), as well as analyses integrating omics and functional investigations, are warranted to further validate and explain the mechanisms of the current findings.
(Less)
- author
- Meng, Xiangyu
and Wang, Qiaoli
LU
- publishing date
- 2024-10-01
- type
- Contribution to journal
- publication status
- published
- keywords
- bladder cancer, FGFR3, sex bias, somatic mutations
- in
- Oncology and Translational Medicine
- volume
- 10
- issue
- 5
- pages
- 252 - 256
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:85208686593
- ISSN
- 2095-9621
- DOI
- 10.1097/ot9.0000000000000054
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: Copyright © 2024 The Author(s).
- id
- 41eced02-6186-4d28-8aa9-6d68e58bb1ac
- date added to LUP
- 2025-05-12 17:17:44
- date last changed
- 2025-05-14 03:37:21
@article{41eced02-6186-4d28-8aa9-6d68e58bb1ac,
abstract = {{<p>Background: Strong sex disparities have been observed among patients with bladder cancer (BCa). FGFR3 is one of the most frequently mutated genes in bladder cancer, and there are inconsistencies in its frequency in male and female patients. Methods: Here, we conducted a meta-analysis comparing the FGFR3 somatic mutation frequency in men and women among 7351 patients with BCa from 18 cohorts. Results: We showed that female patients had a 1.32 times higher risk of having FGFR3 somatic mutations than males. This difference was attributed to mutations occurring at the 2 most frequently mutated sites, S249 and Y375. Additionally, nonsense mutations were more likely to be found in women, whereas indel/frameshift mutations were almost exclusively found in men; however, no difference was noted for missense mutations. Conclusions: A female sex bias in FGFR3 somatic mutations was observed in BCa. Well-powered individual participant data analyses addressing the possible confounding effects of other factors (eg, age, ethnicity, smoking status, muscle invasiveness, and molecular subtype), as well as analyses integrating omics and functional investigations, are warranted to further validate and explain the mechanisms of the current findings.</p>}},
author = {{Meng, Xiangyu and Wang, Qiaoli}},
issn = {{2095-9621}},
keywords = {{bladder cancer; FGFR3; sex bias; somatic mutations}},
language = {{eng}},
month = {{10}},
number = {{5}},
pages = {{252--256}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Oncology and Translational Medicine}},
title = {{Sex bias in FGFR3 somatic mutations in bladder cancer}},
url = {{http://dx.doi.org/10.1097/ot9.0000000000000054}},
doi = {{10.1097/ot9.0000000000000054}},
volume = {{10}},
year = {{2024}},
}