High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people
(2006) In Diabetes 55(1). p.128-135- Abstract
- The insulin-degrading enzyme is responsible for the intracellular proteolysis of insulin. Its gene IDE is located on chromosome 10, in an area with suggestive linkage to type 2 diabetes and related phenotypes. Due to the impact of genetic variants of this gene in rodents and the function of its protein product, it has been proposed as a candidate gene for type 2 diabetes. Various groups have explored the role of the common genetic variation of IDE on insulin resistance and reported associations of various single nucleotide polymorphisms (SNPs) and haplotypes on both type 2 diabetes and glycemic traits. We sought to characterize the haplotype structure of IDE in detail and replicate the association of common variants with type 2 diabetes,... (More)
- The insulin-degrading enzyme is responsible for the intracellular proteolysis of insulin. Its gene IDE is located on chromosome 10, in an area with suggestive linkage to type 2 diabetes and related phenotypes. Due to the impact of genetic variants of this gene in rodents and the function of its protein product, it has been proposed as a candidate gene for type 2 diabetes. Various groups have explored the role of the common genetic variation of IDE on insulin resistance and reported associations of various single nucleotide polymorphisms (SNPs) and haplotypes on both type 2 diabetes and glycemic traits. We sought to characterize the haplotype structure of IDE in detail and replicate the association of common variants with type 2 diabetes, fasting insulin, fasting glucose, and insulin resistance. We assessed linkage disequilibrium, selected single-marker and multimarker tags, and genotyped these markers in several case-control and family-based samples totalling 4,206 Caucasian individuals. We observed no statistically significant evidence of association between single-marker or multimarker tests in IDE and type 2 diabetes. Nominally significant differences in quantitative traits are consistent with statistical noise. We conclude that common genetic variation at, IDE is unlikely to confer clinically significant risk of type 2 diabetes in Caucasians. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/421611
- author
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 55
- issue
- 1
- pages
- 128 - 135
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- wos:000234349500016
- pmid:16380485
- scopus:33644772571
- ISSN
- 1939-327X
- DOI
- 10.2337/diabetes.55.01.06.db05-0954
- language
- English
- LU publication?
- yes
- id
- 58a75b37-8272-440e-950b-a146508bf61e (old id 421611)
- date added to LUP
- 2016-04-01 15:35:23
- date last changed
- 2024-03-22 08:27:31
@article{58a75b37-8272-440e-950b-a146508bf61e, abstract = {{The insulin-degrading enzyme is responsible for the intracellular proteolysis of insulin. Its gene IDE is located on chromosome 10, in an area with suggestive linkage to type 2 diabetes and related phenotypes. Due to the impact of genetic variants of this gene in rodents and the function of its protein product, it has been proposed as a candidate gene for type 2 diabetes. Various groups have explored the role of the common genetic variation of IDE on insulin resistance and reported associations of various single nucleotide polymorphisms (SNPs) and haplotypes on both type 2 diabetes and glycemic traits. We sought to characterize the haplotype structure of IDE in detail and replicate the association of common variants with type 2 diabetes, fasting insulin, fasting glucose, and insulin resistance. We assessed linkage disequilibrium, selected single-marker and multimarker tags, and genotyped these markers in several case-control and family-based samples totalling 4,206 Caucasian individuals. We observed no statistically significant evidence of association between single-marker or multimarker tests in IDE and type 2 diabetes. Nominally significant differences in quantitative traits are consistent with statistical noise. We conclude that common genetic variation at, IDE is unlikely to confer clinically significant risk of type 2 diabetes in Caucasians.}}, author = {{Florez, JC and Wiltshire, S and Agapakis, CM and Burtt, NP and de Bakker, PIW and Almgren, Peter and Bostrom, KB and Tuomi, T and Gaudet, D and Daly, MJ and Hirschhorn, JN and McCarthy, MI and Altshuler, D and Groop, Leif}}, issn = {{1939-327X}}, language = {{eng}}, number = {{1}}, pages = {{128--135}}, publisher = {{American Diabetes Association Inc.}}, series = {{Diabetes}}, title = {{High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people}}, url = {{http://dx.doi.org/10.2337/diabetes.55.01.06.db05-0954}}, doi = {{10.2337/diabetes.55.01.06.db05-0954}}, volume = {{55}}, year = {{2006}}, }