In Vitro Neo-Cartilage Formation on a Three-Dimensional Composite Polymeric Cryogel Matrix
(2013) In Macromolecular Bioscience 13(7). p.827-837- Abstract
- Limited blood supply and the avascular nature of articular cartilage restricts its self repair capacity, frequently leading to osteoarthritis. This work focuses on scaffolds for tissue repair from natural polymers, for example gelatin, chitosan, and agarose in the form of composite. A novel way of fabrication, known as cryogelation, is presented, in which matrices are synthesized at sub-zero temperature. Cell seeded scaffolds incubated under appropriate conditions result in the accumulation of matrix components on the surface of the gel in the form of neo-cartilage. Neo-cartilage exhibits similarity to native cartilage with respect to its physical, mechanical and biochemical properties. Based on the similarities of neo-cartilage to the... (More)
- Limited blood supply and the avascular nature of articular cartilage restricts its self repair capacity, frequently leading to osteoarthritis. This work focuses on scaffolds for tissue repair from natural polymers, for example gelatin, chitosan, and agarose in the form of composite. A novel way of fabrication, known as cryogelation, is presented, in which matrices are synthesized at sub-zero temperature. Cell seeded scaffolds incubated under appropriate conditions result in the accumulation of matrix components on the surface of the gel in the form of neo-cartilage. Neo-cartilage exhibits similarity to native cartilage with respect to its physical, mechanical and biochemical properties. Based on the similarities of neo-cartilage to the native cartilage, it can provide a new approach for the treatment of localised joint injuries. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4273212
- author
- Bhat, Sumrita ; Lidgren, Lars LU and Kumar, Ashok
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- chondrocytes, cryogel scaffolds, extra-cellular matrix, neo-cartilage, osteoarthritis
- in
- Macromolecular Bioscience
- volume
- 13
- issue
- 7
- pages
- 827 - 837
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000327814500002
- scopus:84880698662
- pmid:23619817
- ISSN
- 1616-5195
- DOI
- 10.1002/mabi.201200484
- language
- English
- LU publication?
- yes
- id
- 4579fb6e-9ce9-4786-b017-3f2f1a1f2d2c (old id 4273212)
- date added to LUP
- 2016-04-01 10:57:50
- date last changed
- 2022-02-10 07:40:23
@article{4579fb6e-9ce9-4786-b017-3f2f1a1f2d2c,
abstract = {{Limited blood supply and the avascular nature of articular cartilage restricts its self repair capacity, frequently leading to osteoarthritis. This work focuses on scaffolds for tissue repair from natural polymers, for example gelatin, chitosan, and agarose in the form of composite. A novel way of fabrication, known as cryogelation, is presented, in which matrices are synthesized at sub-zero temperature. Cell seeded scaffolds incubated under appropriate conditions result in the accumulation of matrix components on the surface of the gel in the form of neo-cartilage. Neo-cartilage exhibits similarity to native cartilage with respect to its physical, mechanical and biochemical properties. Based on the similarities of neo-cartilage to the native cartilage, it can provide a new approach for the treatment of localised joint injuries.}},
author = {{Bhat, Sumrita and Lidgren, Lars and Kumar, Ashok}},
issn = {{1616-5195}},
keywords = {{chondrocytes; cryogel scaffolds; extra-cellular matrix; neo-cartilage; osteoarthritis}},
language = {{eng}},
number = {{7}},
pages = {{827--837}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Macromolecular Bioscience}},
title = {{In Vitro Neo-Cartilage Formation on a Three-Dimensional Composite Polymeric Cryogel Matrix}},
url = {{http://dx.doi.org/10.1002/mabi.201200484}},
doi = {{10.1002/mabi.201200484}},
volume = {{13}},
year = {{2013}},
}