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Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.

Thorek, Daniel L J ; Ulmert, David LU ; Diop, Ndeye-Fatou M ; Lupu, Mihaela E ; Doran, Michael G ; Huang, Ruimin ; Abou, Diane S ; Larson, Steven M and Grimm, Jan (2014) In Nature Communications 5(Jan 20).
Abstract
The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, (89)Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling.... (More)
The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, (89)Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that (89)Zr-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
5
issue
Jan 20
article number
3097
publisher
Nature Publishing Group
external identifiers
  • pmid:24445347
  • wos:000331084400006
  • scopus:84892861543
  • pmid:24445347
ISSN
2041-1723
DOI
10.1038/ncomms4097
language
English
LU publication?
yes
id
b8505917-aee0-4471-81f9-1d35355b91c5 (old id 4291013)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24445347?dopt=Abstract
date added to LUP
2016-04-01 13:23:08
date last changed
2022-05-19 19:06:08
@article{b8505917-aee0-4471-81f9-1d35355b91c5,
  abstract     = {{The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, (89)Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that (89)Zr-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging.}},
  author       = {{Thorek, Daniel L J and Ulmert, David and Diop, Ndeye-Fatou M and Lupu, Mihaela E and Doran, Michael G and Huang, Ruimin and Abou, Diane S and Larson, Steven M and Grimm, Jan}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  number       = {{Jan 20}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.}},
  url          = {{http://dx.doi.org/10.1038/ncomms4097}},
  doi          = {{10.1038/ncomms4097}},
  volume       = {{5}},
  year         = {{2014}},
}