Enhanced levels of immunoreactive beta-casomorphin-8 in milk of breastfeeding women with mastitis
(2014) In Peptides 51. p.54-58- Abstract
- An incorrect, superficial suckling technique in breastfeeding frequently leads to milk congestion and sometimes mastitis. In the present study we have examined whether milk congestion may affect levels of the atypical opioid beta-casomorphin-8 in milk and in plasma. We also investigated whether the rate of acute psychosis during the first half year after parturition has declined in Sweden over the years. Milk and plasma samples were collected for peptide analysis from 14 women with mastitis and 10 controls. We found that in a group of 14 late cases of mastitis (median 48 days post partum) the detected mean level of beta-casomorphin-8 in milk was significantly higher and somewhat higher in plasma at the acute stage compared with 2-3 weeks... (More)
- An incorrect, superficial suckling technique in breastfeeding frequently leads to milk congestion and sometimes mastitis. In the present study we have examined whether milk congestion may affect levels of the atypical opioid beta-casomorphin-8 in milk and in plasma. We also investigated whether the rate of acute psychosis during the first half year after parturition has declined in Sweden over the years. Milk and plasma samples were collected for peptide analysis from 14 women with mastitis and 10 controls. We found that in a group of 14 late cases of mastitis (median 48 days post partum) the detected mean level of beta-casomorphin-8 in milk was significantly higher and somewhat higher in plasma at the acute stage compared with 2-3 weeks later, after recovery when the symptoms had disappeared, as well as compared to the control subjects. Swedish official statistics show that the incidence of acute psychosis in the first month and in the first half year after birth has declined by a half during the last 30 years. A relationship between postpartum psychosis and elevated beta-casomorphin-8 levels in CSF has been suggested from earlier studies. In this study, milk congestion led to enhanced levels of beta-casomorphin-8 in milk, which may be related to postpartum psychosis and probably also to the postnatal blues'. (C) 2013 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4327123
- author
- Righard, Lennart LU ; Carlsson-Jonsson, Anna and Nyberg, Fred
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Atypical opioids, beta-Casomorphins, Lactation, Radioimmunoassay, Mastitis, Postpartum psychosis
- in
- Peptides
- volume
- 51
- pages
- 54 - 58
- publisher
- Elsevier
- external identifiers
-
- wos:000329208100009
- scopus:84888145070
- pmid:24189037
- ISSN
- 1873-5169
- DOI
- 10.1016/j.peptides.2013.10.027
- language
- English
- LU publication?
- yes
- id
- fb4436ee-88ec-45b0-952c-0523dd0d31d4 (old id 4327123)
- date added to LUP
- 2016-04-01 10:57:51
- date last changed
- 2022-01-26 04:14:35
@article{fb4436ee-88ec-45b0-952c-0523dd0d31d4,
abstract = {{An incorrect, superficial suckling technique in breastfeeding frequently leads to milk congestion and sometimes mastitis. In the present study we have examined whether milk congestion may affect levels of the atypical opioid beta-casomorphin-8 in milk and in plasma. We also investigated whether the rate of acute psychosis during the first half year after parturition has declined in Sweden over the years. Milk and plasma samples were collected for peptide analysis from 14 women with mastitis and 10 controls. We found that in a group of 14 late cases of mastitis (median 48 days post partum) the detected mean level of beta-casomorphin-8 in milk was significantly higher and somewhat higher in plasma at the acute stage compared with 2-3 weeks later, after recovery when the symptoms had disappeared, as well as compared to the control subjects. Swedish official statistics show that the incidence of acute psychosis in the first month and in the first half year after birth has declined by a half during the last 30 years. A relationship between postpartum psychosis and elevated beta-casomorphin-8 levels in CSF has been suggested from earlier studies. In this study, milk congestion led to enhanced levels of beta-casomorphin-8 in milk, which may be related to postpartum psychosis and probably also to the postnatal blues'. (C) 2013 Elsevier Inc. All rights reserved.}},
author = {{Righard, Lennart and Carlsson-Jonsson, Anna and Nyberg, Fred}},
issn = {{1873-5169}},
keywords = {{Atypical opioids; beta-Casomorphins; Lactation; Radioimmunoassay; Mastitis; Postpartum psychosis}},
language = {{eng}},
pages = {{54--58}},
publisher = {{Elsevier}},
series = {{Peptides}},
title = {{Enhanced levels of immunoreactive beta-casomorphin-8 in milk of breastfeeding women with mastitis}},
url = {{http://dx.doi.org/10.1016/j.peptides.2013.10.027}},
doi = {{10.1016/j.peptides.2013.10.027}},
volume = {{51}},
year = {{2014}},
}