Brain natriuretic peptide is a potent vasodilator in aged human microcirculation and shows a blunted response in heart failure patients.
(2014) In Journal of geriatric cardiology : JGC 11(1). p.50-56- Abstract
- Brain natriuretic peptide (BNP) is normally present in low levels in the circulation, but it is elevated in parallel with the degree of congestion in heart failure subjects (CHF). BNP has natriuretic effects and is a potent vasodilator. It is suggested that BNP could be a therapeutic alternative in CHF. However, we postulated that the high levels of circulating BNP in CHF may downregulate the response of microvascular natriuretic receptors. This was tested by comparing 15 CHF patients (BNP > 3000 ng/L) with 10 matched, healthy controls.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4429730
- author
- Edvinsson, MarieLouise LU ; Uddman, Erik LU ; Edvinsson, Lars LU and Andersson, Sven LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of geriatric cardiology : JGC
- volume
- 11
- issue
- 1
- pages
- 50 - 56
- publisher
- Science Press
- external identifiers
-
- pmid:24748882
- wos:000334078700008
- scopus:84902267895
- pmid:24748882
- ISSN
- 1671-5411
- DOI
- 10.3969/j.issn.1671-5411.2014.01.004
- language
- English
- LU publication?
- yes
- id
- d2320a79-8992-44d3-9031-5e4f30e93db0 (old id 4429730)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24748882?dopt=Abstract
- date added to LUP
- 2016-04-01 13:49:05
- date last changed
- 2024-02-25 06:46:35
@article{d2320a79-8992-44d3-9031-5e4f30e93db0, abstract = {{Brain natriuretic peptide (BNP) is normally present in low levels in the circulation, but it is elevated in parallel with the degree of congestion in heart failure subjects (CHF). BNP has natriuretic effects and is a potent vasodilator. It is suggested that BNP could be a therapeutic alternative in CHF. However, we postulated that the high levels of circulating BNP in CHF may downregulate the response of microvascular natriuretic receptors. This was tested by comparing 15 CHF patients (BNP > 3000 ng/L) with 10 matched, healthy controls.}}, author = {{Edvinsson, MarieLouise and Uddman, Erik and Edvinsson, Lars and Andersson, Sven}}, issn = {{1671-5411}}, language = {{eng}}, number = {{1}}, pages = {{50--56}}, publisher = {{Science Press}}, series = {{Journal of geriatric cardiology : JGC}}, title = {{Brain natriuretic peptide is a potent vasodilator in aged human microcirculation and shows a blunted response in heart failure patients.}}, url = {{https://lup.lub.lu.se/search/files/3609345/4882670.pdf}}, doi = {{10.3969/j.issn.1671-5411.2014.01.004}}, volume = {{11}}, year = {{2014}}, }