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Laboratorial Aspects of Cytolytic Vaginosis and Vulvovaginal Candidiasis as a Key for Accurate Diagnosis : A Pilot Study

Sanches, José Marcos LU ; Giraldo, Paulo César ; Bardin, Marcela Grigol ; Amaral, Rose ; Discacciati, Michelle Garcia and Rossato, Luana (2020) In Revista Brasileira de Ginecologia e Obstetricia 42(10). p.634-641
Abstract

OBJECTIVE:  To identify clinical, microscopic, and biochemical characteristics that differentiate cytolytic vaginosis (CV) from vulvovaginal candidiasis (VVC).

METHODS:  The present cross-sectional study analyzed the vaginal contents of 24 non-pregnant women aged 18 to 42 years who were attended at the Genital Infections Clinic at Centro de Atenção Integral à Saúde da Mulher da Universidade Estadual de Campinas (CAISM-UNICAMP). They were diagnosed either with (CV = 8, VVC = 8) or without vulvovaginitis or vaginal dysbiosis (controls). The socio-demographic, clinical, and gynecological data were obtained from a detailed patient interview. Samples of the vaginal contents were collected for analysis of vaginal pH, gram stain, and... (More)

OBJECTIVE:  To identify clinical, microscopic, and biochemical characteristics that differentiate cytolytic vaginosis (CV) from vulvovaginal candidiasis (VVC).

METHODS:  The present cross-sectional study analyzed the vaginal contents of 24 non-pregnant women aged 18 to 42 years who were attended at the Genital Infections Clinic at Centro de Atenção Integral à Saúde da Mulher da Universidade Estadual de Campinas (CAISM-UNICAMP). They were diagnosed either with (CV = 8, VVC = 8) or without vulvovaginitis or vaginal dysbiosis (controls). The socio-demographic, clinical, and gynecological data were obtained from a detailed patient interview. Samples of the vaginal contents were collected for analysis of vaginal pH, gram stain, and specific fungal culture. The Kruskal-Wallis and Fisher exact tests were used to compare the differences between the groups. Odds ratios were used to compare the categorical variables. The significance level was considered at p < 0.05.

RESULTS:  Both women with CV and VVC had a lumpy vaginal discharge (p = 0,002) and vaginal hyperemia (p = 0.001), compared with controls. The inflammatory process was more intense in the VVC group (p = 0.001). In the CV group, there was statistical significance for the lactobacillus amount (p = 0.006), vaginal epithelium lysis (p = 0.001), and vaginal pH (p = 0.0002).

CONCLUSION:  Cytolytic vaginosis and VVC diagnoses rarely differ on clinical characteristics but have different laboratorial findings. The present study highlights the importance of conducting an accurate investigation through laboratory tests rather than clinical criteria to avoid misdiagnosis.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Revista Brasileira de Ginecologia e Obstetricia
volume
42
issue
10
pages
634 - 641
publisher
Georg Thieme Verlag
external identifiers
  • pmid:33129219
  • scopus:85095388713
ISSN
0100-7203
DOI
10.1055/s-0040-1715139
language
English
LU publication?
no
id
4573cfd3-2a21-43b0-af9d-f5c9c4ffae60
date added to LUP
2021-03-31 14:04:13
date last changed
2024-05-31 23:33:43
@article{4573cfd3-2a21-43b0-af9d-f5c9c4ffae60,
  abstract     = {{<p>OBJECTIVE:  To identify clinical, microscopic, and biochemical characteristics that differentiate cytolytic vaginosis (CV) from vulvovaginal candidiasis (VVC).</p><p>METHODS:  The present cross-sectional study analyzed the vaginal contents of 24 non-pregnant women aged 18 to 42 years who were attended at the Genital Infections Clinic at Centro de Atenção Integral à Saúde da Mulher da Universidade Estadual de Campinas (CAISM-UNICAMP). They were diagnosed either with (CV = 8, VVC = 8) or without vulvovaginitis or vaginal dysbiosis (controls). The socio-demographic, clinical, and gynecological data were obtained from a detailed patient interview. Samples of the vaginal contents were collected for analysis of vaginal pH, gram stain, and specific fungal culture. The Kruskal-Wallis and Fisher exact tests were used to compare the differences between the groups. Odds ratios were used to compare the categorical variables. The significance level was considered at p &lt; 0.05.</p><p>RESULTS:  Both women with CV and VVC had a lumpy vaginal discharge (p = 0,002) and vaginal hyperemia (p = 0.001), compared with controls. The inflammatory process was more intense in the VVC group (p = 0.001). In the CV group, there was statistical significance for the lactobacillus amount (p = 0.006), vaginal epithelium lysis (p = 0.001), and vaginal pH (p = 0.0002).</p><p>CONCLUSION:  Cytolytic vaginosis and VVC diagnoses rarely differ on clinical characteristics but have different laboratorial findings. The present study highlights the importance of conducting an accurate investigation through laboratory tests rather than clinical criteria to avoid misdiagnosis.</p>}},
  author       = {{Sanches, José Marcos and Giraldo, Paulo César and Bardin, Marcela Grigol and Amaral, Rose and Discacciati, Michelle Garcia and Rossato, Luana}},
  issn         = {{0100-7203}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{634--641}},
  publisher    = {{Georg Thieme Verlag}},
  series       = {{Revista Brasileira de Ginecologia e Obstetricia}},
  title        = {{Laboratorial Aspects of Cytolytic Vaginosis and Vulvovaginal Candidiasis as a Key for Accurate Diagnosis : A Pilot Study}},
  url          = {{http://dx.doi.org/10.1055/s-0040-1715139}},
  doi          = {{10.1055/s-0040-1715139}},
  volume       = {{42}},
  year         = {{2020}},
}