The Three Receptor Tyrosine Kinases c-KIT, VEGFR2 and PDGFRα, Closely Spaced at 4q12, Show Increased Protein Expression in Triple-Negative Breast Cancer.
Jansson, Sara LU ; Bendahl, Pär-Ola LU ; Grabau, Dorthe LU ; Falck, Anna-Karin LU ; Fernö, Mårten LU ; Aaltonen, Kristina LU and Rydén, Lisa LU
(2014)
In PLoS ONE
9(7).
- Abstract
- Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer with poor prognosis and no targeted therapy available. Receptor tyrosine kinases (RTKs) are emerging targets in anticancer therapy and many RTK-inhibiting drugs are currently being developed. The aim of this study was to elucidate if there is a correlation between the protein expression of three RTKs c-KIT, VEGFR2 and PDGFRα, their gene copy number, and prognosis in TNBC compared to non-TNBC.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4582246
- author
- Jansson, Sara
LU
; Bendahl, Pär-Ola
LU
; Grabau, Dorthe
LU
; Falck, Anna-Karin
LU
; Fernö, Mårten
LU
; Aaltonen, Kristina
LU
and Rydén, Lisa
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 9
- issue
- 7
- article number
- e102176
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:25025175
- wos:000339992400048
- scopus:84904268803
- pmid:25025175
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0102176
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery (Lund) (013009000), Pathology, (Lund) (013030000), Oncology, MV (013035000)
- id
- eefddef8-f276-4759-8983-20aea091ebd0 (old id 4582246)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25025175?dopt=Abstract
- date added to LUP
- 2016-04-01 13:41:20
- date last changed
- 2022-03-21 19:52:53
@article{eefddef8-f276-4759-8983-20aea091ebd0,
abstract = {{Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer with poor prognosis and no targeted therapy available. Receptor tyrosine kinases (RTKs) are emerging targets in anticancer therapy and many RTK-inhibiting drugs are currently being developed. The aim of this study was to elucidate if there is a correlation between the protein expression of three RTKs c-KIT, VEGFR2 and PDGFRα, their gene copy number, and prognosis in TNBC compared to non-TNBC.}},
author = {{Jansson, Sara and Bendahl, Pär-Ola and Grabau, Dorthe and Falck, Anna-Karin and Fernö, Mårten and Aaltonen, Kristina and Rydén, Lisa}},
issn = {{1932-6203}},
language = {{eng}},
number = {{7}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{The Three Receptor Tyrosine Kinases c-KIT, VEGFR2 and PDGFRα, Closely Spaced at 4q12, Show Increased Protein Expression in Triple-Negative Breast Cancer.}},
url = {{https://lup.lub.lu.se/search/files/3532956/5154500.pdf}},
doi = {{10.1371/journal.pone.0102176}},
volume = {{9}},
year = {{2014}},
}