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97Ru-transferrin uptake in tumor and abscess

Som, P. ; Oster, Z. H. ; Matsui, K. ; Guglielmi, G. ; Persson, B. R.R. LU orcid ; Pellettieri, M. L. ; Srivastava, S. C. ; Richards, P. ; Atkins, H. L. and Brill, A. B. (1983) In European Journal Of Nuclear Medicine 8(11). p.491-494
Abstract

The uptake of97Ru-transferrin (Ru-TF) in tumor and abscess bearing animals was compared with67Ga-citrate (Ga),123I-transferrin (I-TF), and several other plasma proteins. Maximal concentration in tumor of Ru-TF in mice was three times higher than67Ga-citrate (16.80±4.20 vs 5.08±0.58% D/g) although it occurred later (24 h compared with67Ga which reached its maximum 2 h after injection). Whole body autoradiography (WBARG) with103Ru-transferrin (103Ru-TF) in tumor and abscess bearing rats demonstrated details of the distribution within these lesions. Turpentine-induced abscesses in the rabbits could be visualized with the gamma camera as early as 30 min... (More)

The uptake of97Ru-transferrin (Ru-TF) in tumor and abscess bearing animals was compared with67Ga-citrate (Ga),123I-transferrin (I-TF), and several other plasma proteins. Maximal concentration in tumor of Ru-TF in mice was three times higher than67Ga-citrate (16.80±4.20 vs 5.08±0.58% D/g) although it occurred later (24 h compared with67Ga which reached its maximum 2 h after injection). Whole body autoradiography (WBARG) with103Ru-transferrin (103Ru-TF) in tumor and abscess bearing rats demonstrated details of the distribution within these lesions. Turpentine-induced abscesses in the rabbits could be visualized with the gamma camera as early as 30 min post-injection of Ru-TF. It seems, therefore, that Ru-TF can be used for tumor and abscess localization. The results indicate that Ru-TF may have some advantages over67Ga-citrate because of the higher concentration in the lesions.123I-transferrin reached a concentration in tumor similar to67Ga (6.89±1.67 vs 5.08±0.58% D/g) but had a very low tumor to blood ratio (0.64). The three compounds investigated (Ru-TF, I-TF and ionic Ga, which binds instantaneously to TF in vivo) have a common lignad, transferrin. It appears, therefore, that tumor affinity is a property of the radionuclide-ligand complex rather than of the radionuclide itself.

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publishing date
type
Contribution to journal
publication status
published
in
European Journal Of Nuclear Medicine
volume
8
issue
11
pages
4 pages
publisher
Springer
external identifiers
  • scopus:0020972838
  • pmid:6653610
ISSN
0340-6997
DOI
10.1007/BF00598908
language
English
LU publication?
no
id
4677914b-2275-4766-b5fe-fd49ad7d5063
date added to LUP
2020-05-07 21:26:50
date last changed
2024-04-03 06:12:45
@article{4677914b-2275-4766-b5fe-fd49ad7d5063,
  abstract     = {{<p>The uptake of<sup>97</sup>Ru-transferrin (Ru-TF) in tumor and abscess bearing animals was compared with<sup>67</sup>Ga-citrate (Ga),<sup>123</sup>I-transferrin (I-TF), and several other plasma proteins. Maximal concentration in tumor of Ru-TF in mice was three times higher than<sup>67</sup>Ga-citrate (16.80±4.20 vs 5.08±0.58% D/g) although it occurred later (24 h compared with<sup>67</sup>Ga which reached its maximum 2 h after injection). Whole body autoradiography (WBARG) with<sup>103</sup>Ru-transferrin (<sup>103</sup>Ru-TF) in tumor and abscess bearing rats demonstrated details of the distribution within these lesions. Turpentine-induced abscesses in the rabbits could be visualized with the gamma camera as early as 30 min post-injection of Ru-TF. It seems, therefore, that Ru-TF can be used for tumor and abscess localization. The results indicate that Ru-TF may have some advantages over<sup>67</sup>Ga-citrate because of the higher concentration in the lesions.<sup>123</sup>I-transferrin reached a concentration in tumor similar to<sup>67</sup>Ga (6.89±1.67 vs 5.08±0.58% D/g) but had a very low tumor to blood ratio (0.64). The three compounds investigated (Ru-TF, I-TF and ionic Ga, which binds instantaneously to TF in vivo) have a common lignad, transferrin. It appears, therefore, that tumor affinity is a property of the radionuclide-ligand complex rather than of the radionuclide itself.</p>}},
  author       = {{Som, P. and Oster, Z. H. and Matsui, K. and Guglielmi, G. and Persson, B. R.R. and Pellettieri, M. L. and Srivastava, S. C. and Richards, P. and Atkins, H. L. and Brill, A. B.}},
  issn         = {{0340-6997}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{11}},
  pages        = {{491--494}},
  publisher    = {{Springer}},
  series       = {{European Journal Of Nuclear Medicine}},
  title        = {{<sup>97</sup>Ru-transferrin uptake in tumor and abscess}},
  url          = {{http://dx.doi.org/10.1007/BF00598908}},
  doi          = {{10.1007/BF00598908}},
  volume       = {{8}},
  year         = {{1983}},
}