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Biomarker profiling beyond amyloid and tau : cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults

Idland, Ane Victoria ; Sala-Llonch, Roser ; Watne, Leiv Otto ; Brækhus, Anne ; Hansson, Oskar LU orcid ; Blennow, Kaj LU ; Zetterberg, Henrik LU ; Sørensen, Øystein ; Walhovd, Kristine Beate and Wyller, Torgeir Bruun , et al. (2020) In Neurobiology of Aging 93. p.1-15
Abstract

Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n = 99, 64–93 years) with different profiles of the cerebrospinal fluid biomarkers beta amyloid 1–42 (Aβ42), phosphorylated tau (P-tau), total tau, chitinase-3-like protein 1 (YKL-40), fatty acid binding protein 3 (FABP3), and neurofilament light (NFL). Hippocampal volume and memory were assessed across multiple follow-up examinations covering up to 6.8 years. Clustering revealed one group (39%) with more pathological concentrations of all biomarkers, which could further be divided into one group (20%) characterized by tauopathy and high FABP3 and one (19%) by brain β-amyloidosis, high NFL,... (More)

Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n = 99, 64–93 years) with different profiles of the cerebrospinal fluid biomarkers beta amyloid 1–42 (Aβ42), phosphorylated tau (P-tau), total tau, chitinase-3-like protein 1 (YKL-40), fatty acid binding protein 3 (FABP3), and neurofilament light (NFL). Hippocampal volume and memory were assessed across multiple follow-up examinations covering up to 6.8 years. Clustering revealed one group (39%) with more pathological concentrations of all biomarkers, which could further be divided into one group (20%) characterized by tauopathy and high FABP3 and one (19%) by brain β-amyloidosis, high NFL, and slightly higher YKL-40. The clustering approach clearly outperformed classification based on Aβ42 and P-tau alone in prediction of memory decline, with the individuals with most tauopathy and FABP3 showing more memory decline, but not more hippocampal volume change. The results demonstrate that older adults can be classified based on biomarkers beyond amyloid and tau, with improved prediction of memory decline.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Beta amyloid 1–42, Biomarkers, Cerebrospinal fluid, Chitinase-3-like protein 1, Fatty acid binding protein 3, Hippocampal atrophy, Magnetic resonance imaging, Memory, Neurofilament light, Phosphorylated tau, Total tau
in
Neurobiology of Aging
volume
93
pages
15 pages
publisher
Elsevier
external identifiers
  • pmid:32438258
  • scopus:85084636277
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2020.04.002
language
English
LU publication?
yes
id
473394bf-d99a-4292-8f67-5e55f6e8cedb
date added to LUP
2020-06-01 12:49:47
date last changed
2024-04-03 07:07:22
@article{473394bf-d99a-4292-8f67-5e55f6e8cedb,
  abstract     = {{<p>Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n = 99, 64–93 years) with different profiles of the cerebrospinal fluid biomarkers beta amyloid 1–42 (Aβ42), phosphorylated tau (P-tau), total tau, chitinase-3-like protein 1 (YKL-40), fatty acid binding protein 3 (FABP3), and neurofilament light (NFL). Hippocampal volume and memory were assessed across multiple follow-up examinations covering up to 6.8 years. Clustering revealed one group (39%) with more pathological concentrations of all biomarkers, which could further be divided into one group (20%) characterized by tauopathy and high FABP3 and one (19%) by brain β-amyloidosis, high NFL, and slightly higher YKL-40. The clustering approach clearly outperformed classification based on Aβ42 and P-tau alone in prediction of memory decline, with the individuals with most tauopathy and FABP3 showing more memory decline, but not more hippocampal volume change. The results demonstrate that older adults can be classified based on biomarkers beyond amyloid and tau, with improved prediction of memory decline.</p>}},
  author       = {{Idland, Ane Victoria and Sala-Llonch, Roser and Watne, Leiv Otto and Brækhus, Anne and Hansson, Oskar and Blennow, Kaj and Zetterberg, Henrik and Sørensen, Øystein and Walhovd, Kristine Beate and Wyller, Torgeir Bruun and Fjell, Anders Martin}},
  issn         = {{0197-4580}},
  keywords     = {{Beta amyloid 1–42; Biomarkers; Cerebrospinal fluid; Chitinase-3-like protein 1; Fatty acid binding protein 3; Hippocampal atrophy; Magnetic resonance imaging; Memory; Neurofilament light; Phosphorylated tau; Total tau}},
  language     = {{eng}},
  pages        = {{1--15}},
  publisher    = {{Elsevier}},
  series       = {{Neurobiology of Aging}},
  title        = {{Biomarker profiling beyond amyloid and tau : cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults}},
  url          = {{http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.002}},
  doi          = {{10.1016/j.neurobiolaging.2020.04.002}},
  volume       = {{93}},
  year         = {{2020}},
}