Utility of interleukin-6 to identify serious bacterial infections in febrile infants aged ≤60 days
(2024) In Acta Pædiatrica- Abstract
AIM: The aim of this study is to investigate the utility of interleukin-6 (IL-6) in the early diagnosis of serious bacterial infections (SBI) in febrile infants and to compare it with C-reactive protein (CRP).
METHODS: Retrospective study conducted in the paediatric emergency department in Gothenburg, Sweden, on previously healthy, full-term infants aged ≤60 days with fever without a source (FWS) from 2014 to 2017.
RESULTS: We included 536 infants with FWS, of whom IL-6 was analysed in 364 (68%) and CRP was analysed in 494 (92%). Approximately 70% of the infants presented with a fever duration of less than 12 h. The prevalence of SBIs was 14.8% (95% CI,11.3-18.9) in the IL-6 group and 17.8% (95% CI,14.5-21.5) in the CRP... (More)
AIM: The aim of this study is to investigate the utility of interleukin-6 (IL-6) in the early diagnosis of serious bacterial infections (SBI) in febrile infants and to compare it with C-reactive protein (CRP).
METHODS: Retrospective study conducted in the paediatric emergency department in Gothenburg, Sweden, on previously healthy, full-term infants aged ≤60 days with fever without a source (FWS) from 2014 to 2017.
RESULTS: We included 536 infants with FWS, of whom IL-6 was analysed in 364 (68%) and CRP was analysed in 494 (92%). Approximately 70% of the infants presented with a fever duration of less than 12 h. The prevalence of SBIs was 14.8% (95% CI,11.3-18.9) in the IL-6 group and 17.8% (95% CI,14.5-21.5) in the CRP group. The sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of IL-6 ≥50 ng/L were 93%, 66%, 98% and 33%, respectively. For CRP ≥20 mg/L, the sensitivity, specificity, NPV, and PPV were 76%, 89%, 95%, and 55%, respectively. Logistic regression analysis showed that CRP was significantly associated with SBI (p < 0.0001) in the entire population, whereas IL-6 was not.
CONCLUSION: Interleukin-6 showed high sensitivity and NPV, which might assist in identifying SBIs early in febrile infants. However, IL-6 was not shown to be superior to CRP and further studies are needed to investigate whether IL-6 should be incorporated in clinical management.
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- author
- Orfanos, Ioannis LU ; Krusell, Emilie Thorén and Elfving, Kristina LU
- organization
- publishing date
- 2024-09-17
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Acta Pædiatrica
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85204232612
- pmid:39287096
- ISSN
- 1651-2227
- DOI
- 10.1111/apa.17422
- language
- English
- LU publication?
- yes
- additional info
- © 2024 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
- id
- 475a1d99-ed81-4602-b08f-53f996517f9a
- date added to LUP
- 2024-09-25 07:52:44
- date last changed
- 2024-10-10 07:54:22
@article{475a1d99-ed81-4602-b08f-53f996517f9a, abstract = {{<p>AIM: The aim of this study is to investigate the utility of interleukin-6 (IL-6) in the early diagnosis of serious bacterial infections (SBI) in febrile infants and to compare it with C-reactive protein (CRP).</p><p>METHODS: Retrospective study conducted in the paediatric emergency department in Gothenburg, Sweden, on previously healthy, full-term infants aged ≤60 days with fever without a source (FWS) from 2014 to 2017.</p><p>RESULTS: We included 536 infants with FWS, of whom IL-6 was analysed in 364 (68%) and CRP was analysed in 494 (92%). Approximately 70% of the infants presented with a fever duration of less than 12 h. The prevalence of SBIs was 14.8% (95% CI,11.3-18.9) in the IL-6 group and 17.8% (95% CI,14.5-21.5) in the CRP group. The sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of IL-6 ≥50 ng/L were 93%, 66%, 98% and 33%, respectively. For CRP ≥20 mg/L, the sensitivity, specificity, NPV, and PPV were 76%, 89%, 95%, and 55%, respectively. Logistic regression analysis showed that CRP was significantly associated with SBI (p < 0.0001) in the entire population, whereas IL-6 was not.</p><p>CONCLUSION: Interleukin-6 showed high sensitivity and NPV, which might assist in identifying SBIs early in febrile infants. However, IL-6 was not shown to be superior to CRP and further studies are needed to investigate whether IL-6 should be incorporated in clinical management.</p>}}, author = {{Orfanos, Ioannis and Krusell, Emilie Thorén and Elfving, Kristina}}, issn = {{1651-2227}}, language = {{eng}}, month = {{09}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Pædiatrica}}, title = {{Utility of interleukin-6 to identify serious bacterial infections in febrile infants aged ≤60 days}}, url = {{http://dx.doi.org/10.1111/apa.17422}}, doi = {{10.1111/apa.17422}}, year = {{2024}}, }