Positive patch test reactions to oxidized limonene: exposure and relevance
(2014) In Contact Dermatitis 71(5). p.264-272- Abstract
- Background. R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective. To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized R-limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis. Methods. Oxidized R-limonene 3.0% (containing limonene hydroperoxides at 0.33%) in petrolatum was tested in 2900 consecutive dermatitis patients in Australia, Denmark, the United Kingdom, Singapore, Spain,... (More)
- Background. R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective. To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized R-limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis. Methods. Oxidized R-limonene 3.0% (containing limonene hydroperoxides at 0.33%) in petrolatum was tested in 2900 consecutive dermatitis patients in Australia, Denmark, the United Kingdom, Singapore, Spain, and Sweden. A questionnaire assessing exposure to limonene-containing products was completed. Results. Overall, exposure to products containing limonene was found and assessed as being probably relevant for the patients' dermatitis in 36% of the limonene-allergic patients. In Barcelona and Copenhagen, >70% of the patients were judged to have had an exposure to limonene assessed as relevant. Conclusions. Oxidized R-limonene is a common fragrance allergen, and limonene was frequently found in the labelling on the patients' products, and assessed as relevant for the patients' dermatitis. A large number of domestic and occupational sources for contact with R-limonene were identified. (Less)
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- author
- Christensson, Johanna Brared ; Andersen, Klaus E. ; Bruze, Magnus LU ; Johansen, Jeanne D. ; Garcia-Bravo, Begona ; Gimenez Arnau, Ana ; Goh, Chee-Leok ; Nixon, Rosemary and White, Ian R.
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- allergic contact dermatitis, autoxidation, fragrance allergy, hydroperoxide, limonene, oxidation products, patch test, relevance, terpenes
- in
- Contact Dermatitis
- volume
- 71
- issue
- 5
- pages
- 264 - 272
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000344350000002
- scopus:84930240957
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.12285
- language
- English
- LU publication?
- yes
- id
- 1ed94b9d-77ab-4092-8652-00cfb5fe2d96 (old id 4875058)
- date added to LUP
- 2016-04-01 10:44:23
- date last changed
- 2022-05-13 19:48:25
@article{1ed94b9d-77ab-4092-8652-00cfb5fe2d96,
abstract = {{Background. R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective. To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized R-limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis. Methods. Oxidized R-limonene 3.0% (containing limonene hydroperoxides at 0.33%) in petrolatum was tested in 2900 consecutive dermatitis patients in Australia, Denmark, the United Kingdom, Singapore, Spain, and Sweden. A questionnaire assessing exposure to limonene-containing products was completed. Results. Overall, exposure to products containing limonene was found and assessed as being probably relevant for the patients' dermatitis in 36% of the limonene-allergic patients. In Barcelona and Copenhagen, >70% of the patients were judged to have had an exposure to limonene assessed as relevant. Conclusions. Oxidized R-limonene is a common fragrance allergen, and limonene was frequently found in the labelling on the patients' products, and assessed as relevant for the patients' dermatitis. A large number of domestic and occupational sources for contact with R-limonene were identified.}},
author = {{Christensson, Johanna Brared and Andersen, Klaus E. and Bruze, Magnus and Johansen, Jeanne D. and Garcia-Bravo, Begona and Gimenez Arnau, Ana and Goh, Chee-Leok and Nixon, Rosemary and White, Ian R.}},
issn = {{0105-1873}},
keywords = {{allergic contact dermatitis; autoxidation; fragrance allergy; hydroperoxide; limonene; oxidation products; patch test; relevance; terpenes}},
language = {{eng}},
number = {{5}},
pages = {{264--272}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Positive patch test reactions to oxidized limonene: exposure and relevance}},
url = {{http://dx.doi.org/10.1111/cod.12285}},
doi = {{10.1111/cod.12285}},
volume = {{71}},
year = {{2014}},
}