Optimizing the friability of a tablet formulation
Lindberg, N.-O. and Holmquist, Björn LU
(1987)
In Drug Development and Industrial Pharmacy
13(6).
p.1063-1067
- Abstract
- The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4897258
- author
- Lindberg, N.-O.
and Holmquist, Björn
LU
- organization
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Drug Development and Industrial Pharmacy
- volume
- 13
- issue
- 6
- pages
- 1063 - 1067
- publisher
- Marcel Dekker
- external identifiers
-
- scopus:0343073350
- ISSN
- 0363-9045
- DOI
- 10.3109/03639048709068370
- language
- English
- LU publication?
- yes
- id
- 89eb7ce2-9e1c-464e-bef4-26993df6bd26 (old id 4897258)
- date added to LUP
- 2016-04-01 11:53:39
- date last changed
- 2021-01-03 07:00:56
@article{89eb7ce2-9e1c-464e-bef4-26993df6bd26,
abstract = {{The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.}},
author = {{Lindberg, N.-O. and Holmquist, Björn}},
issn = {{0363-9045}},
language = {{eng}},
number = {{6}},
pages = {{1063--1067}},
publisher = {{Marcel Dekker}},
series = {{Drug Development and Industrial Pharmacy}},
title = {{Optimizing the friability of a tablet formulation}},
url = {{http://dx.doi.org/10.3109/03639048709068370}},
doi = {{10.3109/03639048709068370}},
volume = {{13}},
year = {{1987}},
}