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Optimizing the friability of a tablet formulation

Lindberg, N.-O. and Holmquist, Björn LU orcid (1987) In Drug Development and Industrial Pharmacy 13(6). p.1063-1067
Abstract
The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Development and Industrial Pharmacy
volume
13
issue
6
pages
1063 - 1067
publisher
Taylor & Francis
external identifiers
  • scopus:0343073350
ISSN
0363-9045
DOI
10.3109/03639048709068370
language
English
LU publication?
yes
id
89eb7ce2-9e1c-464e-bef4-26993df6bd26 (old id 4897258)
date added to LUP
2016-04-01 11:53:39
date last changed
2025-10-14 12:00:58
@article{89eb7ce2-9e1c-464e-bef4-26993df6bd26,
  abstract     = {{The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.}},
  author       = {{Lindberg, N.-O. and Holmquist, Björn}},
  issn         = {{0363-9045}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1063--1067}},
  publisher    = {{Taylor & Francis}},
  series       = {{Drug Development and Industrial Pharmacy}},
  title        = {{Optimizing the friability of a tablet formulation}},
  url          = {{http://dx.doi.org/10.3109/03639048709068370}},
  doi          = {{10.3109/03639048709068370}},
  volume       = {{13}},
  year         = {{1987}},
}