Theophylline is able to partially revert cachexia in tumour-bearing rats
(2012) In Nutrition & Metabolism 9(1). p.1-8- Abstract
UNLABELLED:
BACKGROUND AND AIMS: The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.
METHODS: The in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment.
RESULTS: Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating... (More)
UNLABELLED:
BACKGROUND AND AIMS: The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.
METHODS: The in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment.
RESULTS: Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating TNF-alpha levels and with a decreased proteolytic systems gene expression. Treatment with the nutraceutical also resulted in an improvement in body composition and cardiac function.
CONCLUSION: Theophylline - alone or in combination with drugs - may be a candidate molecule for the treatment of cancer cachexia.
(Less)
- author
- publishing date
- 2012-08-21
- type
- Contribution to journal
- publication status
- published
- keywords
- Journal Article
- in
- Nutrition & Metabolism
- volume
- 9
- issue
- 1
- article number
- 76
- pages
- 1 - 8
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:22909172
- scopus:84865074747
- ISSN
- 1743-7075
- DOI
- 10.1186/1743-7075-9-76
- language
- English
- LU publication?
- no
- id
- 48a1ef8e-9824-4286-a38c-99ce5fedc042
- date added to LUP
- 2017-02-28 16:12:03
- date last changed
- 2024-05-12 09:20:52
@article{48a1ef8e-9824-4286-a38c-99ce5fedc042,
abstract = {{<p>UNLABELLED: </p><p>BACKGROUND AND AIMS: The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.</p><p>METHODS: The in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment.</p><p>RESULTS: Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating TNF-alpha levels and with a decreased proteolytic systems gene expression. Treatment with the nutraceutical also resulted in an improvement in body composition and cardiac function.</p><p>CONCLUSION: Theophylline - alone or in combination with drugs - may be a candidate molecule for the treatment of cancer cachexia.</p>}},
author = {{Olivan, Mireia and Springer, Jochen and Busquets, Sílvia and Tschirner, Anika and Figueras, Maite and Toledo, Miriam and Fontes-Oliveira, Cibely and Genovese, Maria Inés and Ventura da Silva, Paula and Sette, Angelica and López-Soriano, Francisco J and Anker, Stefan D. and Argilés, Josep M}},
issn = {{1743-7075}},
keywords = {{Journal Article}},
language = {{eng}},
month = {{08}},
number = {{1}},
pages = {{1--8}},
publisher = {{BioMed Central (BMC)}},
series = {{Nutrition & Metabolism}},
title = {{Theophylline is able to partially revert cachexia in tumour-bearing rats}},
url = {{http://dx.doi.org/10.1186/1743-7075-9-76}},
doi = {{10.1186/1743-7075-9-76}},
volume = {{9}},
year = {{2012}},
}