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CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function.

Edvinsson, Lars LU ; Povlsen, Gro Klitgaard ; Ahnstedt, Hilda LU and Waldsee, Roya LU (2014) In Journal of Neuroinflammation 11.
Abstract
It has been suggested that transcriptional upregulation of cerebral artery contractile endothelin (ETB) and 5-hydroxytryptamine (5-HT1B) receptors play an important role in the development of late cerebral ischemia and increased vasoconstriction after subarachnoid hemorrhage (SAH). We tested the hypothesis that inhibition of calcium calmodulin-dependent protein kinase II (CaMKII) may reduce cerebral vasoconstriction mediated by endothelin and serotonin receptors and improve neurological outcome after experimental SAH.
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuroinflammation
volume
11
article number
207
publisher
BioMed Central (BMC)
external identifiers
  • pmid:25498987
  • wos:000347117200001
  • scopus:84924916149
ISSN
1742-2094
DOI
10.1186/s12974-014-0207-2
language
English
LU publication?
yes
id
5a7ed397-d499-4c32-aaef-72c01477fd4e (old id 4908507)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25498987?dopt=Abstract
date added to LUP
2016-04-01 14:31:29
date last changed
2024-01-10 04:56:10
@article{5a7ed397-d499-4c32-aaef-72c01477fd4e,
  abstract     = {{It has been suggested that transcriptional upregulation of cerebral artery contractile endothelin (ETB) and 5-hydroxytryptamine (5-HT1B) receptors play an important role in the development of late cerebral ischemia and increased vasoconstriction after subarachnoid hemorrhage (SAH). We tested the hypothesis that inhibition of calcium calmodulin-dependent protein kinase II (CaMKII) may reduce cerebral vasoconstriction mediated by endothelin and serotonin receptors and improve neurological outcome after experimental SAH.}},
  author       = {{Edvinsson, Lars and Povlsen, Gro Klitgaard and Ahnstedt, Hilda and Waldsee, Roya}},
  issn         = {{1742-2094}},
  language     = {{eng}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Neuroinflammation}},
  title        = {{CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function.}},
  url          = {{https://lup.lub.lu.se/search/files/4019419/7751675}},
  doi          = {{10.1186/s12974-014-0207-2}},
  volume       = {{11}},
  year         = {{2014}},
}