Pitfalls in the interpretation of long-term inhalation experiments
Kjellstrand, Per and Holmquist, Björn LU
(1984)
In Toxicology Letters
21(2).
p.213-218
- Abstract
- Age- and weight-matched groups of mice were enclosed in airtight chambers and exposed to clean, filtered air for 1 month. At the end of the exposure period, body, liver and spleen weights and plasma butyrylcholinesterase (BuChE) activity were measured. More than twice as many significant differences in these parameters occurred compared with the expected results if only random differences existed between the groups. Thus, isolation of animal groups for extended periods of time in inhalation experiments alone may lead to differences in various biological parameters. When testing the effects of unknown substances such differences may be mistaken for reactions to the test agent, which actually may have no effect.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4934172
- author
- Kjellstrand, Per
and Holmquist, Björn
LU
- organization
- publishing date
- 1984
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Body weight, exposure, inhalation, kidney, liver, mouse, spleen
- in
- Toxicology Letters
- volume
- 21
- issue
- 2
- pages
- 213 - 218
- publisher
- Elsevier
- external identifiers
-
- scopus:0021239661
- ISSN
- 1879-3169
- DOI
- 10.1016/0378-4274(84)90209-1
- language
- English
- LU publication?
- yes
- id
- fc1936e5-041b-4c5a-9a78-7963debb822e (old id 4934172)
- date added to LUP
- 2016-04-01 15:44:35
- date last changed
- 2021-01-03 10:20:09
@article{fc1936e5-041b-4c5a-9a78-7963debb822e,
abstract = {{Age- and weight-matched groups of mice were enclosed in airtight chambers and exposed to clean, filtered air for 1 month. At the end of the exposure period, body, liver and spleen weights and plasma butyrylcholinesterase (BuChE) activity were measured. More than twice as many significant differences in these parameters occurred compared with the expected results if only random differences existed between the groups. Thus, isolation of animal groups for extended periods of time in inhalation experiments alone may lead to differences in various biological parameters. When testing the effects of unknown substances such differences may be mistaken for reactions to the test agent, which actually may have no effect.}},
author = {{Kjellstrand, Per and Holmquist, Björn}},
issn = {{1879-3169}},
keywords = {{Body weight; exposure; inhalation; kidney; liver; mouse; spleen}},
language = {{eng}},
number = {{2}},
pages = {{213--218}},
publisher = {{Elsevier}},
series = {{Toxicology Letters}},
title = {{Pitfalls in the interpretation of long-term inhalation experiments}},
url = {{http://dx.doi.org/10.1016/0378-4274(84)90209-1}},
doi = {{10.1016/0378-4274(84)90209-1}},
volume = {{21}},
year = {{1984}},
}