Longitudinal observational study protocol - Preterm Infants : Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO)
Healy, David ; Wang, Shuo ; Grimaud, Ghjuvan LU
; Warda, Alicja Katarzyna
; Ross, Paul
; Stanton, Catherine
and Dempsey, Eugene M.
(2023)
In BMJ Open
13(9).
- Abstract
Introduction Very preterm infants are at risk of abnormal microbiome colonisation in the first weeks to months of life. Several important associated factors have been identified including gestational age, mode of delivery, antibiotic exposure and feeding. Preterm infants are at risk of a number of pathologies for which the microbiome may play a central role, including necrotising enterocolitis and sepsis. The objective of this study is to determine detailed microbiome changes that occur around implementation of different management practices including empiric antibiotic use, advancement of feeds and administration of probiotics during admission to the neonatal intensive care unit. Methods and analysis A single-site, longitudinal... (More)
Introduction Very preterm infants are at risk of abnormal microbiome colonisation in the first weeks to months of life. Several important associated factors have been identified including gestational age, mode of delivery, antibiotic exposure and feeding. Preterm infants are at risk of a number of pathologies for which the microbiome may play a central role, including necrotising enterocolitis and sepsis. The objective of this study is to determine detailed microbiome changes that occur around implementation of different management practices including empiric antibiotic use, advancement of feeds and administration of probiotics during admission to the neonatal intensive care unit. Methods and analysis A single-site, longitudinal observational study of infants born less than 32 weeks gestation, including collection of maternal samples around delivery and breastmilk and infant samples from admission through discharge from the neonatal unit. Ethics and dissemination The protocol was approved by the Clinical Research Ethics Committee of the Cork Teaching Hospitals. The findings from this study will be disseminated in peer-reviewed journals, during scientific conferences, and directly to the study participants. Sequencing data will be deposited in public databases. Trial registration number NCT05803577.
(Less)
- author
- Healy, David
; Wang, Shuo
; Grimaud, Ghjuvan
LU
; Warda, Alicja Katarzyna
; Ross, Paul
; Stanton, Catherine
and Dempsey, Eugene M.
- publishing date
- 2023-09-25
- type
- Contribution to journal
- publication status
- published
- keywords
- Microbiology, Neonatal intensive & critical care, NEONATOLOGY
- in
- BMJ Open
- volume
- 13
- issue
- 9
- article number
- e075060
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:85174060185
- pmid:37748849
- ISSN
- 2044-6055
- DOI
- 10.1136/bmjopen-2023-075060
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2023 BMJ Publishing Group. All rights reserved.
- id
- 497a5f2b-068d-45ef-bc50-a3505dc2c736
- date added to LUP
- 2024-11-25 16:09:34
- date last changed
- 2025-07-08 10:32:13
@article{497a5f2b-068d-45ef-bc50-a3505dc2c736,
abstract = {{<p>Introduction Very preterm infants are at risk of abnormal microbiome colonisation in the first weeks to months of life. Several important associated factors have been identified including gestational age, mode of delivery, antibiotic exposure and feeding. Preterm infants are at risk of a number of pathologies for which the microbiome may play a central role, including necrotising enterocolitis and sepsis. The objective of this study is to determine detailed microbiome changes that occur around implementation of different management practices including empiric antibiotic use, advancement of feeds and administration of probiotics during admission to the neonatal intensive care unit. Methods and analysis A single-site, longitudinal observational study of infants born less than 32 weeks gestation, including collection of maternal samples around delivery and breastmilk and infant samples from admission through discharge from the neonatal unit. Ethics and dissemination The protocol was approved by the Clinical Research Ethics Committee of the Cork Teaching Hospitals. The findings from this study will be disseminated in peer-reviewed journals, during scientific conferences, and directly to the study participants. Sequencing data will be deposited in public databases. Trial registration number NCT05803577.</p>}},
author = {{Healy, David and Wang, Shuo and Grimaud, Ghjuvan and Warda, Alicja Katarzyna and Ross, Paul and Stanton, Catherine and Dempsey, Eugene M.}},
issn = {{2044-6055}},
keywords = {{Microbiology; Neonatal intensive & critical care; NEONATOLOGY}},
language = {{eng}},
month = {{09}},
number = {{9}},
publisher = {{BMJ Publishing Group}},
series = {{BMJ Open}},
title = {{Longitudinal observational study protocol - Preterm Infants : Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO)}},
url = {{http://dx.doi.org/10.1136/bmjopen-2023-075060}},
doi = {{10.1136/bmjopen-2023-075060}},
volume = {{13}},
year = {{2023}},
}