Transforming spinal surgery with innovations in biologics and additive manufacturing
(2025) In Materials Today Bio 32.- Abstract
The synergistic integration of biologics and additive manufacturing (AM) technologies has catalyzed groundbreaking advancements in spinal surgery. These innovations address persistent challenges, such as optimizing fusion outcomes, enhancing tissue regeneration, and achieving precise anatomical compatibility. Biologics have transformed spinal fusion by facilitating bone formation and promoting osteointegration through refinements in traditional materials and cutting-edge biologic developments. Concurrently, AM technologies, including 3D printing and biofabrication, enable the design and production of patient-specific implants and bioengineered scaffolds, significantly enhancing surgical precision and improving treatment outcomes. This... (More)
The synergistic integration of biologics and additive manufacturing (AM) technologies has catalyzed groundbreaking advancements in spinal surgery. These innovations address persistent challenges, such as optimizing fusion outcomes, enhancing tissue regeneration, and achieving precise anatomical compatibility. Biologics have transformed spinal fusion by facilitating bone formation and promoting osteointegration through refinements in traditional materials and cutting-edge biologic developments. Concurrently, AM technologies, including 3D printing and biofabrication, enable the design and production of patient-specific implants and bioengineered scaffolds, significantly enhancing surgical precision and improving treatment outcomes. This review underscores the transformative synergy of biologics and AM, offering a comprehensive exploration of their applications in preclinical research and clinical practice. Together, these synergistic advancements are redefining the field of spinal surgery, driving the evolution of personalized and innovative treatment paradigms.
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- author
- Tian, Xinggui LU ; Liu, Yakui ; Liu, Suihong ; Tian, Qinyu ; Raina, Deepak Bushan LU ; Gelinsky, Michael and Zwingenberger, Stefan
- organization
- publishing date
- 2025-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Additive manufacturing, Biologics, Regenerative medicine, Spine surgery
- in
- Materials Today Bio
- volume
- 32
- article number
- 101853
- publisher
- Elsevier
- external identifiers
-
- pmid:40487177
- scopus:105005078798
- ISSN
- 2590-0064
- DOI
- 10.1016/j.mtbio.2025.101853
- language
- English
- LU publication?
- yes
- id
- 498efdc7-bce4-4aa2-a923-4e20c5351662
- date added to LUP
- 2025-08-01 08:55:37
- date last changed
- 2025-08-02 03:00:08
@article{498efdc7-bce4-4aa2-a923-4e20c5351662,
abstract = {{<p>The synergistic integration of biologics and additive manufacturing (AM) technologies has catalyzed groundbreaking advancements in spinal surgery. These innovations address persistent challenges, such as optimizing fusion outcomes, enhancing tissue regeneration, and achieving precise anatomical compatibility. Biologics have transformed spinal fusion by facilitating bone formation and promoting osteointegration through refinements in traditional materials and cutting-edge biologic developments. Concurrently, AM technologies, including 3D printing and biofabrication, enable the design and production of patient-specific implants and bioengineered scaffolds, significantly enhancing surgical precision and improving treatment outcomes. This review underscores the transformative synergy of biologics and AM, offering a comprehensive exploration of their applications in preclinical research and clinical practice. Together, these synergistic advancements are redefining the field of spinal surgery, driving the evolution of personalized and innovative treatment paradigms.</p>}},
author = {{Tian, Xinggui and Liu, Yakui and Liu, Suihong and Tian, Qinyu and Raina, Deepak Bushan and Gelinsky, Michael and Zwingenberger, Stefan}},
issn = {{2590-0064}},
keywords = {{Additive manufacturing; Biologics; Regenerative medicine; Spine surgery}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Materials Today Bio}},
title = {{Transforming spinal surgery with innovations in biologics and additive manufacturing}},
url = {{http://dx.doi.org/10.1016/j.mtbio.2025.101853}},
doi = {{10.1016/j.mtbio.2025.101853}},
volume = {{32}},
year = {{2025}},
}