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Trends in the prevalence, incidence and survival of non-Hodgkin lymphoma subtypes during the 21st century – a Swedish lymphoma register study

Ekberg, Sara ; E. Smedby, Karin ; Glimelius, Ingrid ; Nilsson-Ehle, Herman ; Goldkuhl, Christina ; Lewerin, Catharina ; Jerkeman, Mats LU and Eloranta, Sandra (2020) In British Journal of Haematology 189(6). p.1083-1092
Abstract

Non-Hodgkin lymphoma (NHL) prognosis has improved in recent years, yet the number of patients living with the diagnosis, i.e. the prevalence, has seldom been reported. The prevalence provides a measure of the burden of disease, useful for healthcare planning and to optimise resource allocation. We provide a systematic presentation of temporal trends in absolute numbers of prevalent patients by NHL subtypes, linking them to trends in incidence, survival and mortality. Patients diagnosed 2000–2016 were identified in the national Swedish lymphoma register. Incidence and mortality rates, relative survival and prevalence were estimated for NHL overall and for major clinical and morphological subtypes. Poisson regression was used to test for... (More)

Non-Hodgkin lymphoma (NHL) prognosis has improved in recent years, yet the number of patients living with the diagnosis, i.e. the prevalence, has seldom been reported. The prevalence provides a measure of the burden of disease, useful for healthcare planning and to optimise resource allocation. We provide a systematic presentation of temporal trends in absolute numbers of prevalent patients by NHL subtypes, linking them to trends in incidence, survival and mortality. Patients diagnosed 2000–2016 were identified in the national Swedish lymphoma register. Incidence and mortality rates, relative survival and prevalence were estimated for NHL overall and for major clinical and morphological subtypes. Poisson regression was used to test for temporal trends. Increasing incidence and improved survival have led to a 47% increase in the five-year prevalence of NHL overall in 2016 compared to 2004. An increasing prevalence was observed for all investigated subtypes during the study period, but most notably for diffuse large B cell lymphomas among aggressive subtypes (66%), and marginal zone lymphomas among indolent subtypes (135%). This dramatic increase in NHL prevalence underscores the need to develop and evaluate alternative follow-up schemes to use resources efficiently and still ensure optimal care of lymphoma survivors.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
incidence, non-Hodgkin lymphoma, prevalence, survival
in
British Journal of Haematology
volume
189
issue
6
pages
10 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85079714936
  • pmid:32065396
ISSN
0007-1048
DOI
10.1111/bjh.16489
language
English
LU publication?
yes
id
4a7dc0ad-bd30-4ce2-a035-eb75457b7bd9
date added to LUP
2020-03-04 13:36:16
date last changed
2024-06-12 09:54:30
@article{4a7dc0ad-bd30-4ce2-a035-eb75457b7bd9,
  abstract     = {{<p>Non-Hodgkin lymphoma (NHL) prognosis has improved in recent years, yet the number of patients living with the diagnosis, i.e. the prevalence, has seldom been reported. The prevalence provides a measure of the burden of disease, useful for healthcare planning and to optimise resource allocation. We provide a systematic presentation of temporal trends in absolute numbers of prevalent patients by NHL subtypes, linking them to trends in incidence, survival and mortality. Patients diagnosed 2000–2016 were identified in the national Swedish lymphoma register. Incidence and mortality rates, relative survival and prevalence were estimated for NHL overall and for major clinical and morphological subtypes. Poisson regression was used to test for temporal trends. Increasing incidence and improved survival have led to a 47% increase in the five-year prevalence of NHL overall in 2016 compared to 2004. An increasing prevalence was observed for all investigated subtypes during the study period, but most notably for diffuse large B cell lymphomas among aggressive subtypes (66%), and marginal zone lymphomas among indolent subtypes (135%). This dramatic increase in NHL prevalence underscores the need to develop and evaluate alternative follow-up schemes to use resources efficiently and still ensure optimal care of lymphoma survivors.</p>}},
  author       = {{Ekberg, Sara and E. Smedby, Karin and Glimelius, Ingrid and Nilsson-Ehle, Herman and Goldkuhl, Christina and Lewerin, Catharina and Jerkeman, Mats and Eloranta, Sandra}},
  issn         = {{0007-1048}},
  keywords     = {{incidence; non-Hodgkin lymphoma; prevalence; survival}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1083--1092}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{British Journal of Haematology}},
  title        = {{Trends in the prevalence, incidence and survival of non-Hodgkin lymphoma subtypes during the 21st century – a Swedish lymphoma register study}},
  url          = {{http://dx.doi.org/10.1111/bjh.16489}},
  doi          = {{10.1111/bjh.16489}},
  volume       = {{189}},
  year         = {{2020}},
}