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Regional differences in arachidonic acid release in rat hippocampal CA1 and CA3 regions during cerebral ischemia

Westerberg, E. ; Deshpande, J. K. and Wieloch, T. LU (1987) In Journal of Cerebral Blood Flow and Metabolism 7(2). p.189-192
Abstract

Changes in the levels of arachidonic acid during ischemia in selectively vulnerable areas of the hippocampus were studied in the rat brain. Since neurons in the CA1 region are more vulnerable to ischemia than neurons in the adjacent CA3 region, the release of arachidonic acid in these two regions was measured during decapitation ischemia of 4- to 12-min duration. The concentration of free arachidonic acid increased with the duration of ischemia in both regions. However, the level was significantly higher in CA1 than in CA3 after 8 and 12 min of ischemia. This difference in arachidonic acid accumulation may reflect differences between the regions in agonist-dependent phospholipid breakdown as... (More)

Changes in the levels of arachidonic acid during ischemia in selectively vulnerable areas of the hippocampus were studied in the rat brain. Since neurons in the CA1 region are more vulnerable to ischemia than neurons in the adjacent CA3 region, the release of arachidonic acid in these two regions was measured during decapitation ischemia of 4- to 12-min duration. The concentration of free arachidonic acid increased with the duration of ischemia in both regions. However, the level was significantly higher in CA1 than in CA3 after 8 and 12 min of ischemia. This difference in arachidonic acid accumulation may reflect differences between the regions in agonist-dependent phospholipid breakdown as well as calcium-dependent phospholipase activity. The importance for the development of neuronal necrosis is discussed.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cerebral Blood Flow and Metabolism
volume
7
issue
2
pages
4 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:0023187307
  • pmid:3104354
ISSN
0271-678X
DOI
10.1038/jcbfm.1987.43
language
English
LU publication?
yes
id
4ff53522-b064-45de-b9b0-751b54962e5f
date added to LUP
2019-06-13 17:43:57
date last changed
2024-01-01 10:31:51
@article{4ff53522-b064-45de-b9b0-751b54962e5f,
  abstract     = {{<p>Changes in the levels of arachidonic acid during ischemia in selectively vulnerable areas of the hippocampus were studied in the rat brain. Since neurons in the CA<sub>1</sub> region are more vulnerable to ischemia than neurons in the adjacent CA<sub>3</sub> region, the release of arachidonic acid in these two regions was measured during decapitation ischemia of 4- to 12-min duration. The concentration of free arachidonic acid increased with the duration of ischemia in both regions. However, the level was significantly higher in CA<sub>1</sub> than in CA<sub>3</sub> after 8 and 12 min of ischemia. This difference in arachidonic acid accumulation may reflect differences between the regions in agonist-dependent phospholipid breakdown as well as calcium-dependent phospholipase activity. The importance for the development of neuronal necrosis is discussed.</p>}},
  author       = {{Westerberg, E. and Deshpande, J. K. and Wieloch, T.}},
  issn         = {{0271-678X}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{2}},
  pages        = {{189--192}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Journal of Cerebral Blood Flow and Metabolism}},
  title        = {{Regional differences in arachidonic acid release in rat hippocampal CA<sub>1</sub> and CA<sub>3</sub> regions during cerebral ischemia}},
  url          = {{http://dx.doi.org/10.1038/jcbfm.1987.43}},
  doi          = {{10.1038/jcbfm.1987.43}},
  volume       = {{7}},
  year         = {{1987}},
}