Pituitary adenylate cyclase activating polypeptide and migraine.
(2014) In Annals of Clinical and Translational Neurology 1(12). p.1036-1040- Abstract
- Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg (n = 11), and further reduced interictally (n = 9). The data suggest PACAP, or its receptors, are a promising target for migraine therapeutics.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5040891
- author
- Zagami, Alessandro S ; Edvinsson, Lars LU and Goadsby, Peter J
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of Clinical and Translational Neurology
- volume
- 1
- issue
- 12
- pages
- 1036 - 1040
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:25574477
- pmid:25574477
- scopus:84929476563
- wos:000209815800007
- ISSN
- 2328-9503
- DOI
- 10.1002/acn3.113
- language
- English
- LU publication?
- yes
- id
- 1632c028-2dbf-4da7-b8b3-8fd1bc9d3c43 (old id 5040891)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25574477?dopt=Abstract
- date added to LUP
- 2016-04-01 14:34:19
- date last changed
- 2024-02-08 17:47:19
@article{1632c028-2dbf-4da7-b8b3-8fd1bc9d3c43,
abstract = {{Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg (n = 11), and further reduced interictally (n = 9). The data suggest PACAP, or its receptors, are a promising target for migraine therapeutics.}},
author = {{Zagami, Alessandro S and Edvinsson, Lars and Goadsby, Peter J}},
issn = {{2328-9503}},
language = {{eng}},
number = {{12}},
pages = {{1036--1040}},
publisher = {{Wiley-Blackwell}},
series = {{Annals of Clinical and Translational Neurology}},
title = {{Pituitary adenylate cyclase activating polypeptide and migraine.}},
url = {{https://lup.lub.lu.se/search/files/4042774/7753859}},
doi = {{10.1002/acn3.113}},
volume = {{1}},
year = {{2014}},
}