Analysis of manganese and iron in exhaled endogenous particles
(2014) In Journal of Analytical Atomic Spectrometry p.730-735- Abstract
- Many full-time welders experience some sort of respiratory disorder e.g., asthma, bronchitis and metal fume fever. Thus, welding aerosols are thought to cause airway inflammation. There is a need for markers of welding aerosols in exposure assessments, and as most welding aerosols contain manganese and iron, these metals may possibly be used as an indicator. We have previously developed a novel non-invasive technique to collect endogenous particles in exhaled air (PEx). This study is designed to (i) develop a method for analysis of manganese and iron in PEx and (ii) investigate whether the manganese and/or iron content of PEx changes after exposure to welding aerosols. Methods: nine individuals were experimentally exposed to welding fumes.... (More)
- Many full-time welders experience some sort of respiratory disorder e.g., asthma, bronchitis and metal fume fever. Thus, welding aerosols are thought to cause airway inflammation. There is a need for markers of welding aerosols in exposure assessments, and as most welding aerosols contain manganese and iron, these metals may possibly be used as an indicator. We have previously developed a novel non-invasive technique to collect endogenous particles in exhaled air (PEx). This study is designed to (i) develop a method for analysis of manganese and iron in PEx and (ii) investigate whether the manganese and/or iron content of PEx changes after exposure to welding aerosols. Methods: nine individuals were experimentally exposed to welding fumes. PEx was collected at three time points for each individual; before, after and 24 hours after exposure. Analyses of PEx samples were performed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Results: four out of nine individuals showed an increase in manganese and iron levels after exposure to welding aerosols. The mean manganese and iron concentration increased from, <LOD to 82–84 pg L−1 (range from 0 to LOD for values <LOD) and 20–86 to 2600 pg L−1 of exhaled air respectively. Conclusions: an ICP-MS method for analysis of manganese and iron in PEx has been developed. The method could easily be expanded to include other trace metals of interest, such as cadmium, nickel or chromium. This first attempt to evaluate PEx as a tool for exposure assessments of airborne metals indicates that the method has potential. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5051252
- author
- Bredberg, Anna ; Ljungkvist, Göran ; Taube, Fabian ; Ljungström, Evert ; Larsson, Per ; Mirgorodskaya, Ekaterina ; Isaxon, Christina LU ; Gudmundsson, Anders LU ; Forsgard, Niklas and Ohlin, Anna-Carin
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Analytical Atomic Spectrometry
- issue
- 29
- pages
- 730 - 735
- publisher
- Royal Society of Chemistry
- external identifiers
-
- scopus:84900672959
- wos:000333660100015
- ISSN
- 1364-5544
- DOI
- 10.1039/C3JA50381J
- language
- English
- LU publication?
- yes
- id
- 6ed3bef5-f8d4-4104-b4c0-f63771389241 (old id 5051252)
- alternative location
- http://pubs.rsc.org/en/content/articlehtml/2014/ja/c3ja50381j
- date added to LUP
- 2016-04-01 10:33:07
- date last changed
- 2022-02-17 19:14:31
@article{6ed3bef5-f8d4-4104-b4c0-f63771389241, abstract = {{Many full-time welders experience some sort of respiratory disorder e.g., asthma, bronchitis and metal fume fever. Thus, welding aerosols are thought to cause airway inflammation. There is a need for markers of welding aerosols in exposure assessments, and as most welding aerosols contain manganese and iron, these metals may possibly be used as an indicator. We have previously developed a novel non-invasive technique to collect endogenous particles in exhaled air (PEx). This study is designed to (i) develop a method for analysis of manganese and iron in PEx and (ii) investigate whether the manganese and/or iron content of PEx changes after exposure to welding aerosols. Methods: nine individuals were experimentally exposed to welding fumes. PEx was collected at three time points for each individual; before, after and 24 hours after exposure. Analyses of PEx samples were performed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Results: four out of nine individuals showed an increase in manganese and iron levels after exposure to welding aerosols. The mean manganese and iron concentration increased from, <LOD to 82–84 pg L−1 (range from 0 to LOD for values <LOD) and 20–86 to 2600 pg L−1 of exhaled air respectively. Conclusions: an ICP-MS method for analysis of manganese and iron in PEx has been developed. The method could easily be expanded to include other trace metals of interest, such as cadmium, nickel or chromium. This first attempt to evaluate PEx as a tool for exposure assessments of airborne metals indicates that the method has potential.}}, author = {{Bredberg, Anna and Ljungkvist, Göran and Taube, Fabian and Ljungström, Evert and Larsson, Per and Mirgorodskaya, Ekaterina and Isaxon, Christina and Gudmundsson, Anders and Forsgard, Niklas and Ohlin, Anna-Carin}}, issn = {{1364-5544}}, language = {{eng}}, number = {{29}}, pages = {{730--735}}, publisher = {{Royal Society of Chemistry}}, series = {{Journal of Analytical Atomic Spectrometry}}, title = {{Analysis of manganese and iron in exhaled endogenous particles}}, url = {{http://dx.doi.org/10.1039/C3JA50381J}}, doi = {{10.1039/C3JA50381J}}, year = {{2014}}, }