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Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism

Zhou, Qishun ; Kerbl-Knapp, Jakob ; Zhang, Fangrong ; Korbelius, Melanie ; Kuentzel, Katharina Barbara LU orcid ; Vujić, Nemanja ; Akhmetshina, Alena ; Hörl, Gerd ; Paar, Margret and Steyrer, Ernst , et al. (2021) In Metabolites 12(1).
Abstract

Energy metabolism, including alterations in energy intake and expenditure, is closely related to aging and longevity. Metabolomics studies have recently unraveled changes in metabolite composition in plasma and tissues during aging and have provided critical information to elucidate the molecular basis of the aging process. However, the metabolic changes in tissues responsible for food intake and lipid storage have remained unexplored. In this study, we aimed to investigate aging-related metabolic alterations in these tissues. To fill this gap, we employed NMR-based metabolomics in several tissues, including different parts of the intestine (duodenum, jejunum, ileum) and brown/white adipose tissues (BAT, WAT), of young (9-10 weeks) and... (More)

Energy metabolism, including alterations in energy intake and expenditure, is closely related to aging and longevity. Metabolomics studies have recently unraveled changes in metabolite composition in plasma and tissues during aging and have provided critical information to elucidate the molecular basis of the aging process. However, the metabolic changes in tissues responsible for food intake and lipid storage have remained unexplored. In this study, we aimed to investigate aging-related metabolic alterations in these tissues. To fill this gap, we employed NMR-based metabolomics in several tissues, including different parts of the intestine (duodenum, jejunum, ileum) and brown/white adipose tissues (BAT, WAT), of young (9-10 weeks) and old (96-104 weeks) wild-type (mixed genetic background of 129/J and C57BL/6) mice. We, further, included plasma and skeletal muscle of the same mice to verify previous results. Strikingly, we found that duodenum, jejunum, ileum, and WAT do not metabolically age. In contrast, plasma, skeletal muscle, and BAT show a strong metabolic aging phenotype. Overall, we provide first insights into the metabolic changes of tissues essential for nutrient uptake and lipid storage and have identified biomarkers for metabolites that could be further explored, to study the molecular mechanisms of aging.

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publishing date
type
Contribution to journal
publication status
published
in
Metabolites
volume
12
issue
1
article number
17
publisher
MDPI AG
external identifiers
  • pmid:35050139
  • scopus:85121865752
ISSN
2218-1989
DOI
10.3390/metabo12010017
language
English
LU publication?
no
id
50d8b65c-123d-4306-81df-ad4f80e70156
date added to LUP
2022-10-10 16:28:03
date last changed
2024-06-27 15:56:11
@article{50d8b65c-123d-4306-81df-ad4f80e70156,
  abstract     = {{<p>Energy metabolism, including alterations in energy intake and expenditure, is closely related to aging and longevity. Metabolomics studies have recently unraveled changes in metabolite composition in plasma and tissues during aging and have provided critical information to elucidate the molecular basis of the aging process. However, the metabolic changes in tissues responsible for food intake and lipid storage have remained unexplored. In this study, we aimed to investigate aging-related metabolic alterations in these tissues. To fill this gap, we employed NMR-based metabolomics in several tissues, including different parts of the intestine (duodenum, jejunum, ileum) and brown/white adipose tissues (BAT, WAT), of young (9-10 weeks) and old (96-104 weeks) wild-type (mixed genetic background of 129/J and C57BL/6) mice. We, further, included plasma and skeletal muscle of the same mice to verify previous results. Strikingly, we found that duodenum, jejunum, ileum, and WAT do not metabolically age. In contrast, plasma, skeletal muscle, and BAT show a strong metabolic aging phenotype. Overall, we provide first insights into the metabolic changes of tissues essential for nutrient uptake and lipid storage and have identified biomarkers for metabolites that could be further explored, to study the molecular mechanisms of aging.</p>}},
  author       = {{Zhou, Qishun and Kerbl-Knapp, Jakob and Zhang, Fangrong and Korbelius, Melanie and Kuentzel, Katharina Barbara and Vujić, Nemanja and Akhmetshina, Alena and Hörl, Gerd and Paar, Margret and Steyrer, Ernst and Kratky, Dagmar and Madl, Tobias}},
  issn         = {{2218-1989}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{1}},
  publisher    = {{MDPI AG}},
  series       = {{Metabolites}},
  title        = {{Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism}},
  url          = {{http://dx.doi.org/10.3390/metabo12010017}},
  doi          = {{10.3390/metabo12010017}},
  volume       = {{12}},
  year         = {{2021}},
}