Generation of an integration-free induced pluripotent stem cell line (CSC-43J) from a patient with sporadic Parkinson's disease
(2018) In Stem Cell Research 27. p.82-85- Abstract
An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5171f550-724d-4b35-b329-cbb973824f73
- author
- Marote, Ana LU ; Pomeshchik, Yuriy LU ; Goldwurm, Stefano ; Collin, Anna LU ; Lamas, Nuno J. LU ; Pinto, Luísa ; Salgado, António J. and Roybon, Laurent LU
- organization
- publishing date
- 2018-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Stem Cell Research
- volume
- 27
- pages
- 4 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:29334630
- scopus:85040374677
- ISSN
- 1873-5061
- DOI
- 10.1016/j.scr.2018.01.007
- language
- English
- LU publication?
- yes
- id
- 5171f550-724d-4b35-b329-cbb973824f73
- date added to LUP
- 2018-01-22 08:51:06
- date last changed
- 2024-10-14 20:23:58
@article{5171f550-724d-4b35-b329-cbb973824f73, abstract = {{<p>An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.</p>}}, author = {{Marote, Ana and Pomeshchik, Yuriy and Goldwurm, Stefano and Collin, Anna and Lamas, Nuno J. and Pinto, Luísa and Salgado, António J. and Roybon, Laurent}}, issn = {{1873-5061}}, language = {{eng}}, month = {{03}}, pages = {{82--85}}, publisher = {{Elsevier}}, series = {{Stem Cell Research}}, title = {{Generation of an integration-free induced pluripotent stem cell line (CSC-43J) from a patient with sporadic Parkinson's disease}}, url = {{http://dx.doi.org/10.1016/j.scr.2018.01.007}}, doi = {{10.1016/j.scr.2018.01.007}}, volume = {{27}}, year = {{2018}}, }