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Reduced content of chloroatranol and atranol in oak moss absolute significantly reduces the elicitation potential of this fragrance material

Andersen, Flemming ; Andersen, Kirsten H. ; Bernois, Armand ; Brault, Christophe ; Bruze, Magnus LU ; Eudes, Herve ; Gadras, Catherine ; Signoret, Anne-Cecile J. ; Mose, Kristian F. and Mueller, Boris P. , et al. (2015) In Contact Dermatitis 72(2). p.75-83
Abstract
BackgroundOak moss absolute, an extract from the lichen Evernia prunastri, is a valued perfume ingredient but contains extreme allergens. ObjectivesTo compare the elicitation properties of two preparations of oak moss absolute: classic oak moss', the historically used preparation, and new oak moss', with reduced contents of the major allergens atranol and chloroatranol. Patients/materials/methodsThe two preparations were compared in randomized double-blinded repeated open application tests and serial dilution patch tests in 30 oak moss-sensitive volunteers and 30 non-allergic control subjects. ResultsIn both test models, new oak moss elicited significantly less allergic contact dermatitis in oak moss-sensitive subjects than classic oak... (More)
BackgroundOak moss absolute, an extract from the lichen Evernia prunastri, is a valued perfume ingredient but contains extreme allergens. ObjectivesTo compare the elicitation properties of two preparations of oak moss absolute: classic oak moss', the historically used preparation, and new oak moss', with reduced contents of the major allergens atranol and chloroatranol. Patients/materials/methodsThe two preparations were compared in randomized double-blinded repeated open application tests and serial dilution patch tests in 30 oak moss-sensitive volunteers and 30 non-allergic control subjects. ResultsIn both test models, new oak moss elicited significantly less allergic contact dermatitis in oak moss-sensitive subjects than classic oak moss. The control subjects did not react to either of the preparations. ConclusionsNew oak moss is still a fragrance allergen, but elicits less allergic contact dermatitis in previously oak moss-sensitized individuals, suggesting that new oak moss is less allergenic to non-sensitized individuals. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic contact dermatitis, fragrances, patch test, risk assessment
in
Contact Dermatitis
volume
72
issue
2
pages
75 - 83
publisher
Wiley-Blackwell
external identifiers
  • wos:000348742500002
  • scopus:84921405663
  • pmid:25395354
ISSN
0105-1873
DOI
10.1111/cod.12312
language
English
LU publication?
yes
id
41084ca5-1f37-43a6-8e18-f3916b01c6af (old id 5187083)
date added to LUP
2016-04-01 10:52:36
date last changed
2022-07-21 21:26:53
@article{41084ca5-1f37-43a6-8e18-f3916b01c6af,
  abstract     = {{BackgroundOak moss absolute, an extract from the lichen Evernia prunastri, is a valued perfume ingredient but contains extreme allergens. ObjectivesTo compare the elicitation properties of two preparations of oak moss absolute: classic oak moss', the historically used preparation, and new oak moss', with reduced contents of the major allergens atranol and chloroatranol. Patients/materials/methodsThe two preparations were compared in randomized double-blinded repeated open application tests and serial dilution patch tests in 30 oak moss-sensitive volunteers and 30 non-allergic control subjects. ResultsIn both test models, new oak moss elicited significantly less allergic contact dermatitis in oak moss-sensitive subjects than classic oak moss. The control subjects did not react to either of the preparations. ConclusionsNew oak moss is still a fragrance allergen, but elicits less allergic contact dermatitis in previously oak moss-sensitized individuals, suggesting that new oak moss is less allergenic to non-sensitized individuals.}},
  author       = {{Andersen, Flemming and Andersen, Kirsten H. and Bernois, Armand and Brault, Christophe and Bruze, Magnus and Eudes, Herve and Gadras, Catherine and Signoret, Anne-Cecile J. and Mose, Kristian F. and Mueller, Boris P. and Toulemonde, Bernard and Andersen, Klaus Ejner}},
  issn         = {{0105-1873}},
  keywords     = {{allergic contact dermatitis; fragrances; patch test; risk assessment}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{75--83}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Reduced content of chloroatranol and atranol in oak moss absolute significantly reduces the elicitation potential of this fragrance material}},
  url          = {{http://dx.doi.org/10.1111/cod.12312}},
  doi          = {{10.1111/cod.12312}},
  volume       = {{72}},
  year         = {{2015}},
}