Chemical Methods for Detection of Allergens and Skin Exposure
(2020) p.631-652- Abstract
Many allergens are widely used in both consumer and occupational products. In many cases, it is difficult to know all the ingredients of a product since most products are not sufficiently labelled. To diagnose and prevent allergic contact dermatitis, the demonstration of allergens in the products from the patient’s environment is important. Chemical analysis of a product can make it possible to demonstrate the presence or absence of known allergens. Simple spot tests or documented analytical methods such as thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), gas chromatography (GC), atomic absorption spectrophotometry (AAS), and inductively coupled plasma-mass spectrometry (ICP-MS) can be used. Moreover, with... (More)
Many allergens are widely used in both consumer and occupational products. In many cases, it is difficult to know all the ingredients of a product since most products are not sufficiently labelled. To diagnose and prevent allergic contact dermatitis, the demonstration of allergens in the products from the patient’s environment is important. Chemical analysis of a product can make it possible to demonstrate the presence or absence of known allergens. Simple spot tests or documented analytical methods such as thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), gas chromatography (GC), atomic absorption spectrophotometry (AAS), and inductively coupled plasma-mass spectrometry (ICP-MS) can be used. Moreover, with chemical methods, the purity of a substance can be checked and new allergens can be isolated and identified. Advanced methods such as mass spectrometry (MS), nuclear magnetic resonance spectroscopy (NMR), and infrared spectrophotometry (IR) are often required to identify isolated allergens.
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- author
- Dahlin, Jakob LU ; Svedman, Cecilia LU ; Gruvberger, Birgitta LU ; Bruze, Magnus LU ; Lidén, Carola and Fregert, Sigfrid LU
- organization
- publishing date
- 2020
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Acid wipe sampling, Atomic absorption, Bag rinsing, Chemical analysis, Chromate, Cobalt, Epoxy, Extract, Fluorescent tracer, Formaldehyde, Gas chromatography, IR, Liquid chromatography, Mass spectrometry, Nickel, NMR, Skin exposure assessment, Spectrophotometry, Spot test, Surrogate skin sampling, Tape stripping, Thin layer chromatography, UV
- host publication
- Contact Dermatitis : Sixth Edition - Sixth Edition
- pages
- 22 pages
- publisher
- Springer International Publishing
- external identifiers
-
- scopus:85149548108
- ISBN
- 9783030363345
- 9783030363352
- DOI
- 10.1007/978-3-030-36335-2_27
- language
- English
- LU publication?
- yes
- id
- 51b67ca9-56e4-4896-a3cb-5bf5e30bc15b
- date added to LUP
- 2023-04-04 12:51:53
- date last changed
- 2024-09-05 23:43:47
@inbook{51b67ca9-56e4-4896-a3cb-5bf5e30bc15b, abstract = {{<p>Many allergens are widely used in both consumer and occupational products. In many cases, it is difficult to know all the ingredients of a product since most products are not sufficiently labelled. To diagnose and prevent allergic contact dermatitis, the demonstration of allergens in the products from the patient’s environment is important. Chemical analysis of a product can make it possible to demonstrate the presence or absence of known allergens. Simple spot tests or documented analytical methods such as thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), gas chromatography (GC), atomic absorption spectrophotometry (AAS), and inductively coupled plasma-mass spectrometry (ICP-MS) can be used. Moreover, with chemical methods, the purity of a substance can be checked and new allergens can be isolated and identified. Advanced methods such as mass spectrometry (MS), nuclear magnetic resonance spectroscopy (NMR), and infrared spectrophotometry (IR) are often required to identify isolated allergens.</p>}}, author = {{Dahlin, Jakob and Svedman, Cecilia and Gruvberger, Birgitta and Bruze, Magnus and Lidén, Carola and Fregert, Sigfrid}}, booktitle = {{Contact Dermatitis : Sixth Edition}}, isbn = {{9783030363345}}, keywords = {{Acid wipe sampling; Atomic absorption; Bag rinsing; Chemical analysis; Chromate; Cobalt; Epoxy; Extract; Fluorescent tracer; Formaldehyde; Gas chromatography; IR; Liquid chromatography; Mass spectrometry; Nickel; NMR; Skin exposure assessment; Spectrophotometry; Spot test; Surrogate skin sampling; Tape stripping; Thin layer chromatography; UV}}, language = {{eng}}, pages = {{631--652}}, publisher = {{Springer International Publishing}}, title = {{Chemical Methods for Detection of Allergens and Skin Exposure}}, url = {{http://dx.doi.org/10.1007/978-3-030-36335-2_27}}, doi = {{10.1007/978-3-030-36335-2_27}}, year = {{2020}}, }