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RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.

Goel, Suchi ; Palmkvist, Mia ; Moll, Kirsten ; Joannin, Nicolas ; Lara, Patricia ; R Akhouri, Reetesh ; Moradi, Nasim ; Öjemalm, Karin ; Westman, Mattias and Angeletti, Davide , et al. (2015) In Nature Medicine 21(4). p.314-317
Abstract
Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Medicine
volume
21
issue
4
pages
314 - 317
publisher
Nature Publishing Group
external identifiers
  • pmid:25751816
  • wos:000352493600012
  • scopus:84926684537
  • pmid:25751816
ISSN
1546-170X
DOI
10.1038/nm.3812
language
English
LU publication?
yes
id
63ededd1-b81d-44d4-8675-d9e2109c1370 (old id 5265001)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25751816?dopt=Abstract
date added to LUP
2016-04-01 10:31:20
date last changed
2022-04-27 22:53:06
@article{63ededd1-b81d-44d4-8675-d9e2109c1370,
  abstract     = {{Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.}},
  author       = {{Goel, Suchi and Palmkvist, Mia and Moll, Kirsten and Joannin, Nicolas and Lara, Patricia and R Akhouri, Reetesh and Moradi, Nasim and Öjemalm, Karin and Westman, Mattias and Angeletti, Davide and Kjellin, Hanna and Lehtiö, Janne and Blixt, Ola and Ideström, Lars and Gahmberg, Carl G and Storry, Jill and Hult, Annika and Olsson, Martin L and von Heijne, Gunnar and Nilsson, IngMarie and Wahlgren, Mats}},
  issn         = {{1546-170X}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{314--317}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Medicine}},
  title        = {{RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.}},
  url          = {{http://dx.doi.org/10.1038/nm.3812}},
  doi          = {{10.1038/nm.3812}},
  volume       = {{21}},
  year         = {{2015}},
}