Salvage cryotherapy for local recurrence after radiotherapy for prostate cancer
(2015) In Scandinavian Journal of Urology 49(2). p.115-119- Abstract
- Objective. The aim of this study was to present the outcome of patients treated with salvage cryotherapy after radiotherapy for prostate cancer at one institution. Materials and methods. Consecutive patients treated between 2007 and 2013 with transperineal cryotherapy for biopsy-verified local recurrence after radiotherapy were investigated. An external reviewer retrieved outcome data retrospectively from medical records. Complications were graded according to the Clavien classification. One patient with less than 1 year of follow-up was excluded from the analysis of side-effects. Results. Thirty patients were included, 29 of whom had a follow-up of at least 1 year. The median follow-up was 2.7 years (range 1-6.5 years). Eleven of the 23... (More)
- Objective. The aim of this study was to present the outcome of patients treated with salvage cryotherapy after radiotherapy for prostate cancer at one institution. Materials and methods. Consecutive patients treated between 2007 and 2013 with transperineal cryotherapy for biopsy-verified local recurrence after radiotherapy were investigated. An external reviewer retrieved outcome data retrospectively from medical records. Complications were graded according to the Clavien classification. One patient with less than 1 year of follow-up was excluded from the analysis of side-effects. Results. Thirty patients were included, 29 of whom had a follow-up of at least 1 year. The median follow-up was 2.7 years (range 1-6.5 years). Eleven of the 23 patients without hormonal treatment at the time of cryotherapy reached a prostate-specific antigen (PSA) nadir of less than 0.5 ng/ml. At the end of follow-up five of these 23 patients still had a PSA below 0.5 ng/ml and 10 were free from recurrence according to the Phoenix definition. Clinical recurrence (verified with imaging or biopsies) was detected in 13 patients, six of which were local. One patient died from prostate cancer. Eleven patients had urinary incontinence grade 1-2 and three had grade 3-4, seven had pelvic pain, three had severe but transitory tissue sloughing, three developed a urethral stricture or had prolonged urinary retention, and one developed a urinary fistula 4.5 years after cryotherapy. Conclusions. Salvage cryotherapy should be considered as an alternative to hormonal treatment and surgery for local recurrence after radiotherapy for prostate cancer. The results compare well to those reported from centres with longer experience. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5281983
- author
- Ternov, Klara Kvorning ; Krag Jakobsen, Ane LU ; Bratt, Ola LU and Ahlgren, Göran LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cryotherapy, prostate cancer, salvage
- in
- Scandinavian Journal of Urology
- volume
- 49
- issue
- 2
- pages
- 115 - 119
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000351395600006
- scopus:84924980600
- pmid:25428754
- ISSN
- 2168-1813
- DOI
- 10.3109/21681805.2014.968869
- language
- English
- LU publication?
- yes
- id
- a5e5a422-baaf-4307-a67a-0acee63c5b03 (old id 5281983)
- date added to LUP
- 2016-04-01 10:31:16
- date last changed
- 2022-05-17 23:41:13
@article{a5e5a422-baaf-4307-a67a-0acee63c5b03,
abstract = {{Objective. The aim of this study was to present the outcome of patients treated with salvage cryotherapy after radiotherapy for prostate cancer at one institution. Materials and methods. Consecutive patients treated between 2007 and 2013 with transperineal cryotherapy for biopsy-verified local recurrence after radiotherapy were investigated. An external reviewer retrieved outcome data retrospectively from medical records. Complications were graded according to the Clavien classification. One patient with less than 1 year of follow-up was excluded from the analysis of side-effects. Results. Thirty patients were included, 29 of whom had a follow-up of at least 1 year. The median follow-up was 2.7 years (range 1-6.5 years). Eleven of the 23 patients without hormonal treatment at the time of cryotherapy reached a prostate-specific antigen (PSA) nadir of less than 0.5 ng/ml. At the end of follow-up five of these 23 patients still had a PSA below 0.5 ng/ml and 10 were free from recurrence according to the Phoenix definition. Clinical recurrence (verified with imaging or biopsies) was detected in 13 patients, six of which were local. One patient died from prostate cancer. Eleven patients had urinary incontinence grade 1-2 and three had grade 3-4, seven had pelvic pain, three had severe but transitory tissue sloughing, three developed a urethral stricture or had prolonged urinary retention, and one developed a urinary fistula 4.5 years after cryotherapy. Conclusions. Salvage cryotherapy should be considered as an alternative to hormonal treatment and surgery for local recurrence after radiotherapy for prostate cancer. The results compare well to those reported from centres with longer experience.}},
author = {{Ternov, Klara Kvorning and Krag Jakobsen, Ane and Bratt, Ola and Ahlgren, Göran}},
issn = {{2168-1813}},
keywords = {{Cryotherapy; prostate cancer; salvage}},
language = {{eng}},
number = {{2}},
pages = {{115--119}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Urology}},
title = {{Salvage cryotherapy for local recurrence after radiotherapy for prostate cancer}},
url = {{http://dx.doi.org/10.3109/21681805.2014.968869}},
doi = {{10.3109/21681805.2014.968869}},
volume = {{49}},
year = {{2015}},
}