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Polymer mobilization and drug release during tablet swelling. A 1H NMR and NMR microimaging study

Dahlberg, Carina LU ; Fureby, Anna LU ; Schuleit, Michael ; Dvinskikh, Sergey V. and Furó, István (2007) In Journal of Controlled Release 122(2). p.199-205
Abstract

The objective of this study was to investigate the swelling characteristics of a hydroxypropyl methylcellulose (HPMC) matrix incorporating the hydrophilic drug antipyrine. We have used this matrix to introduce a novel analytical method, which allows us to obtain within one experimental setup information about the molecular processes of the polymer carrier and its impact on drug release. Nuclear magnetic resonance (NMR) imaging revealed in situ the swelling behavior of tablets when exposed to water. By using deuterated water, the spatial distribution and molecular dynamics of HPMC and their kinetics during swelling could be observed selectively. In parallel, NMR spectroscopy provided the concentration of the drug released into the... (More)

The objective of this study was to investigate the swelling characteristics of a hydroxypropyl methylcellulose (HPMC) matrix incorporating the hydrophilic drug antipyrine. We have used this matrix to introduce a novel analytical method, which allows us to obtain within one experimental setup information about the molecular processes of the polymer carrier and its impact on drug release. Nuclear magnetic resonance (NMR) imaging revealed in situ the swelling behavior of tablets when exposed to water. By using deuterated water, the spatial distribution and molecular dynamics of HPMC and their kinetics during swelling could be observed selectively. In parallel, NMR spectroscopy provided the concentration of the drug released into the aqueous phase. We find that both swelling and release are diffusion controlled. The ability of monitoring those two processes using the same experimental setup enables mapping their interconnection, which points on the importance and potential of this analytical technique for further application in other drug delivery forms.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Diffusion, Gel formation, Hydroxypropyl methylcellulose, Magnetic resonance imaging, Nuclear magnetic resonance spectroscopy, Swelling
in
Journal of Controlled Release
volume
122
issue
2
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:34548451110
  • pmid:17706829
ISSN
0168-3659
DOI
10.1016/j.jconrel.2007.07.007
language
English
LU publication?
no
id
5288951d-886f-48bd-8888-ca0858f7fe92
date added to LUP
2025-04-02 22:38:23
date last changed
2025-05-29 02:47:58
@article{5288951d-886f-48bd-8888-ca0858f7fe92,
  abstract     = {{<p>The objective of this study was to investigate the swelling characteristics of a hydroxypropyl methylcellulose (HPMC) matrix incorporating the hydrophilic drug antipyrine. We have used this matrix to introduce a novel analytical method, which allows us to obtain within one experimental setup information about the molecular processes of the polymer carrier and its impact on drug release. Nuclear magnetic resonance (NMR) imaging revealed in situ the swelling behavior of tablets when exposed to water. By using deuterated water, the spatial distribution and molecular dynamics of HPMC and their kinetics during swelling could be observed selectively. In parallel, NMR spectroscopy provided the concentration of the drug released into the aqueous phase. We find that both swelling and release are diffusion controlled. The ability of monitoring those two processes using the same experimental setup enables mapping their interconnection, which points on the importance and potential of this analytical technique for further application in other drug delivery forms.</p>}},
  author       = {{Dahlberg, Carina and Fureby, Anna and Schuleit, Michael and Dvinskikh, Sergey V. and Furó, István}},
  issn         = {{0168-3659}},
  keywords     = {{Diffusion; Gel formation; Hydroxypropyl methylcellulose; Magnetic resonance imaging; Nuclear magnetic resonance spectroscopy; Swelling}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{2}},
  pages        = {{199--205}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Controlled Release}},
  title        = {{Polymer mobilization and drug release during tablet swelling. A <sup>1</sup>H NMR and NMR microimaging study}},
  url          = {{http://dx.doi.org/10.1016/j.jconrel.2007.07.007}},
  doi          = {{10.1016/j.jconrel.2007.07.007}},
  volume       = {{122}},
  year         = {{2007}},
}