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Vascular effects of helodermin, helospectin I and helospectin II : a comparison with vasoactive intestinal peptide (VIP)

Grundemar, L LU and Högestätt, E D LU (1990) In British Journal of Pharmacology 99(3). p.526-528
Abstract

1. Helodermin, helospectin I and helospectin II, peptides recently isolated from the salivary gland venom of Heloderma suspectum, were compared to vasoactive intestinal peptide (VIP) with respect to effects on systemic blood pressure and on isolated femoral arteries in the rat. 2. They all reduced blood pressure in a dose-dependent manner; helodermin was less effective than VIP. However, at doses higher than 1 nmol kg-1 all four peptides reduced blood pressure to about the same extent. 3. The half-life of the hypotensive effect of VIP was longer than that of helodermin and the helospectins. 4. VIP and helodermin were equally potent in relaxing femoral arteries precontracted with phenylephrine or prostaglandin F2 alpha. 5. Helospectin I... (More)

1. Helodermin, helospectin I and helospectin II, peptides recently isolated from the salivary gland venom of Heloderma suspectum, were compared to vasoactive intestinal peptide (VIP) with respect to effects on systemic blood pressure and on isolated femoral arteries in the rat. 2. They all reduced blood pressure in a dose-dependent manner; helodermin was less effective than VIP. However, at doses higher than 1 nmol kg-1 all four peptides reduced blood pressure to about the same extent. 3. The half-life of the hypotensive effect of VIP was longer than that of helodermin and the helospectins. 4. VIP and helodermin were equally potent in relaxing femoral arteries precontracted with phenylephrine or prostaglandin F2 alpha. 5. Helospectin I and II relaxed phenylephrine-contracted vessels to the same extent as VIP but with a lower potency. 6. Addition of VIP 1 microM to preparations exposed to helodermin 1 microM or to either of the helospectins did not produce a further relaxation. 7. The findings indicate that VIP, helodermin and helospectin I and II have a similar profile of action and therefore may act on a common receptor.

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keywords
Amino Acid Sequence, Animals, Blood Pressure/drug effects, Dinoprost/pharmacology, Female, Half-Life, Hemodynamics/drug effects, In Vitro Techniques, Male, Molecular Sequence Data, Peptides/pharmacology, Phenylephrine/pharmacology, Rats, Rats, Inbred Strains, Vasoactive Intestinal Peptide/pharmacology
in
British Journal of Pharmacology
volume
99
issue
3
pages
526 - 528
publisher
Wiley
external identifiers
  • scopus:0025020117
  • pmid:2331581
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1990.tb12962.x
language
English
LU publication?
yes
id
541d0ccf-8280-4359-9c82-80b46dd7d923
date added to LUP
2019-09-03 14:12:41
date last changed
2024-07-11 04:12:08
@article{541d0ccf-8280-4359-9c82-80b46dd7d923,
  abstract     = {{<p>1. Helodermin, helospectin I and helospectin II, peptides recently isolated from the salivary gland venom of Heloderma suspectum, were compared to vasoactive intestinal peptide (VIP) with respect to effects on systemic blood pressure and on isolated femoral arteries in the rat. 2. They all reduced blood pressure in a dose-dependent manner; helodermin was less effective than VIP. However, at doses higher than 1 nmol kg-1 all four peptides reduced blood pressure to about the same extent. 3. The half-life of the hypotensive effect of VIP was longer than that of helodermin and the helospectins. 4. VIP and helodermin were equally potent in relaxing femoral arteries precontracted with phenylephrine or prostaglandin F2 alpha. 5. Helospectin I and II relaxed phenylephrine-contracted vessels to the same extent as VIP but with a lower potency. 6. Addition of VIP 1 microM to preparations exposed to helodermin 1 microM or to either of the helospectins did not produce a further relaxation. 7. The findings indicate that VIP, helodermin and helospectin I and II have a similar profile of action and therefore may act on a common receptor.</p>}},
  author       = {{Grundemar, L and Högestätt, E D}},
  issn         = {{0007-1188}},
  keywords     = {{Amino Acid Sequence; Animals; Blood Pressure/drug effects; Dinoprost/pharmacology; Female; Half-Life; Hemodynamics/drug effects; In Vitro Techniques; Male; Molecular Sequence Data; Peptides/pharmacology; Phenylephrine/pharmacology; Rats; Rats, Inbred Strains; Vasoactive Intestinal Peptide/pharmacology}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{526--528}},
  publisher    = {{Wiley}},
  series       = {{British Journal of Pharmacology}},
  title        = {{Vascular effects of helodermin, helospectin I and helospectin II : a comparison with vasoactive intestinal peptide (VIP)}},
  url          = {{http://dx.doi.org/10.1111/j.1476-5381.1990.tb12962.x}},
  doi          = {{10.1111/j.1476-5381.1990.tb12962.x}},
  volume       = {{99}},
  year         = {{1990}},
}