OARSI Clinical Trials Recommendations: Key analytic considerations in design, analysis, and reporting of randomized controlled trials in osteoarthritis.
(2015) In Osteoarthritis and Cartilage 23(5). p.677-685- Abstract
- To highlight methodologic challenges pertinent to design, analysis, and reporting of results of randomized clinical trials in OA and offer practical suggestions to overcome these challenges. The topics covered in this paper include subject selection, randomization, approaches to handling missing data, subgroup analysis, sample size, and issues related to changing design mid-way through the study. Special attention is given to standardizing the reporting of results and economic analyses. Key findings include the importance of blinding and concealment, the distinction between superiority and non-inferiority trials, the need to minimize missing data, and appropriate analysis and interpretation of subgroup effects. Investigators may use the... (More)
- To highlight methodologic challenges pertinent to design, analysis, and reporting of results of randomized clinical trials in OA and offer practical suggestions to overcome these challenges. The topics covered in this paper include subject selection, randomization, approaches to handling missing data, subgroup analysis, sample size, and issues related to changing design mid-way through the study. Special attention is given to standardizing the reporting of results and economic analyses. Key findings include the importance of blinding and concealment, the distinction between superiority and non-inferiority trials, the need to minimize missing data, and appropriate analysis and interpretation of subgroup effects. Investigators may use the findings and recommendations advanced in this paper to guide design and conduct of randomized controlled trials of interventions for osteoarthritis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5456721
- author
- Losina, E ; Ranstam, Jonas LU ; Collins, J E ; Schnitzer, T J and Katz, J N
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Osteoarthritis and Cartilage
- volume
- 23
- issue
- 5
- pages
- 677 - 685
- publisher
- Elsevier
- external identifiers
-
- pmid:25952341
- wos:000353821200003
- scopus:84933528472
- pmid:25952341
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2015.03.011
- language
- English
- LU publication?
- yes
- id
- 1f9d906f-f4e7-4038-9b38-ca8961a959db (old id 5456721)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25952341?dopt=Abstract
- date added to LUP
- 2016-04-01 10:54:32
- date last changed
- 2022-02-17 22:29:33
@article{1f9d906f-f4e7-4038-9b38-ca8961a959db,
abstract = {{To highlight methodologic challenges pertinent to design, analysis, and reporting of results of randomized clinical trials in OA and offer practical suggestions to overcome these challenges. The topics covered in this paper include subject selection, randomization, approaches to handling missing data, subgroup analysis, sample size, and issues related to changing design mid-way through the study. Special attention is given to standardizing the reporting of results and economic analyses. Key findings include the importance of blinding and concealment, the distinction between superiority and non-inferiority trials, the need to minimize missing data, and appropriate analysis and interpretation of subgroup effects. Investigators may use the findings and recommendations advanced in this paper to guide design and conduct of randomized controlled trials of interventions for osteoarthritis.}},
author = {{Losina, E and Ranstam, Jonas and Collins, J E and Schnitzer, T J and Katz, J N}},
issn = {{1063-4584}},
language = {{eng}},
number = {{5}},
pages = {{677--685}},
publisher = {{Elsevier}},
series = {{Osteoarthritis and Cartilage}},
title = {{OARSI Clinical Trials Recommendations: Key analytic considerations in design, analysis, and reporting of randomized controlled trials in osteoarthritis.}},
url = {{http://dx.doi.org/10.1016/j.joca.2015.03.011}},
doi = {{10.1016/j.joca.2015.03.011}},
volume = {{23}},
year = {{2015}},
}