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Progenitor cells in the postnatal central nervous system, characterization and genetic manipulation

Rogelius, Nina LU (2007)
Abstract
New neurons are only generated in two places of the postnatal brain; the subventricular zone (SVZ) and hippocampus. The SVZ-derived cells specifically migrate to the olfactory bulb where they give rise to new interneurons. We have genetically manipulated the postnatal SVZ progenitor cells with the aim to direct them to a neuronal fate in the striatum. Our result showed that ectopic expression of the transcription factors Islet1 and Neurogenin2 directed the SVZ cells progeny to a new fate in the striatum and external capsule. Once removed to the culture dish they expressed the neuronal marker ?-III-tubulin. Thus, showing that ectopic expression of Islet1 and Neurogenin2 in the postnatal SVZ progenitor cells promote striatal recruitment for... (More)
New neurons are only generated in two places of the postnatal brain; the subventricular zone (SVZ) and hippocampus. The SVZ-derived cells specifically migrate to the olfactory bulb where they give rise to new interneurons. We have genetically manipulated the postnatal SVZ progenitor cells with the aim to direct them to a neuronal fate in the striatum. Our result showed that ectopic expression of the transcription factors Islet1 and Neurogenin2 directed the SVZ cells progeny to a new fate in the striatum and external capsule. Once removed to the culture dish they expressed the neuronal marker ?-III-tubulin. Thus, showing that ectopic expression of Islet1 and Neurogenin2 in the postnatal SVZ progenitor cells promote striatal recruitment for their progeny, which have potential to differentiate into neurons. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Professor Eriksson, Peter, Sektionen för klinisk neurovetenskap och rehabilitering
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Medicin (människa och djur), Medicine (human and vertebrates), subventricular zone, Islet1, Neurogenin2, respecification, in vivo., transcription factors, neurogenesis, Progenitor cells, stem cells
pages
126 pages
publisher
Department of Experimental Medical Science, Lund Univeristy
defense location
Segerfalksalen, Wallenberg Neurocentrum, Lund.
defense date
2007-06-09 09:00:00
ISBN
978-91-85559-84-8
language
English
LU publication?
yes
additional info
Nina Rogelius, Cecilia Ericson and Cecilia Lundberg. 2005. In vivo labeling of neuroblasts in the subventricular zone of rats. J Neurosci Methods, vol 142 pp 285-293.
Nina Rogelius, B Josephine Jensen, Cecilia Lundberg and Malin Parmar. 2006. Retrovirally delivered Islet-1 increases recruitment of ng2 expressing cells from the postnatal SVZ into the striatum. Experimental Neurology, vol 201 pp 388-398.
Nina Rogelius, B Josephine Jensen, Cecilia Lundberg and Malin Parmar. . Expression of Isl1 and Ngn2 in neonatal SVZ results in a striatal cell populatioin with potential for neuronal differentiation. (submitted)
id
f271a778-1af7-48cd-8858-fb1f5dd8692e (old id 548782)
date added to LUP
2016-04-01 15:46:10
date last changed
2018-11-21 20:36:13
@phdthesis{f271a778-1af7-48cd-8858-fb1f5dd8692e,
  abstract     = {{New neurons are only generated in two places of the postnatal brain; the subventricular zone (SVZ) and hippocampus. The SVZ-derived cells specifically migrate to the olfactory bulb where they give rise to new interneurons. We have genetically manipulated the postnatal SVZ progenitor cells with the aim to direct them to a neuronal fate in the striatum. Our result showed that ectopic expression of the transcription factors Islet1 and Neurogenin2 directed the SVZ cells progeny to a new fate in the striatum and external capsule. Once removed to the culture dish they expressed the neuronal marker ?-III-tubulin. Thus, showing that ectopic expression of Islet1 and Neurogenin2 in the postnatal SVZ progenitor cells promote striatal recruitment for their progeny, which have potential to differentiate into neurons.}},
  author       = {{Rogelius, Nina}},
  isbn         = {{978-91-85559-84-8}},
  keywords     = {{Medicin (människa och djur); Medicine (human and vertebrates); subventricular zone; Islet1; Neurogenin2; respecification; in vivo.; transcription factors; neurogenesis; Progenitor cells; stem cells}},
  language     = {{eng}},
  publisher    = {{Department of Experimental Medical Science, Lund Univeristy}},
  school       = {{Lund University}},
  title        = {{Progenitor cells in the postnatal central nervous system, characterization and genetic manipulation}},
  url          = {{https://lup.lub.lu.se/search/files/4466182/548784.pdf}},
  year         = {{2007}},
}