Urinary tract anomalies and urinary tract dysfunction in children with Hirschsprung disease—Is follow-up indicated?
Granéli, C. LU ; Marschall Sima, H. ; Börjesson, A. LU ; Hagelsteen, K. LU
; Arnbjörnsson, E.
LU
and Stenström, P.
LU
(2019)
In Journal of Pediatric Surgery
54(10).
p.2012-2016
- Abstract
Background/Purpose: Urinary tract function in children with Hirschsprung disease (HD) is rarely considered. Aim: to evaluate the prevalence of urinary tract anomalies and dysfunction in children with HD compared to controls. Methods: This was an observational cross sectional case–control study. Children with HD who underwent transanal endorectal pull-through technique (TERPT) from 2005 to 2017 were invited to participate. Ultrasound of the urinary tract was performed postoperatively. Children > 4 years were asked to answer a urinary tract function questionnaire. Controls were age-matched healthy children. Ethical approval was obtained. Results: Seventy two children with HD and TERPT were included. Ultrasound was performed in 58... (More)
Background/Purpose: Urinary tract function in children with Hirschsprung disease (HD) is rarely considered. Aim: to evaluate the prevalence of urinary tract anomalies and dysfunction in children with HD compared to controls. Methods: This was an observational cross sectional case–control study. Children with HD who underwent transanal endorectal pull-through technique (TERPT) from 2005 to 2017 were invited to participate. Ultrasound of the urinary tract was performed postoperatively. Children > 4 years were asked to answer a urinary tract function questionnaire. Controls were age-matched healthy children. Ethical approval was obtained. Results: Seventy two children with HD and TERPT were included. Ultrasound was performed in 58 children (83%) post-TERPT. Ten anomalies were diagnosed in six children (10%). Structural anomalies included abnormal kidney size (7%), renal agenesis (2%), prominent calyces (2%) and renal pelvis anomaly (25). Probable acquired anomalies included hydronephrosis (2%), hydroureter (2%) and parenchymal damage (2%). One child had a prior nephrectomy owing to a Wilms’ tumor. All 37 children > 4 years (27 boys and 10 girls), median aged 8 years (range 4–12), answered the questionnaire as did 284 healthy controls (144 boys and 140 girls). Boys with HD reported a higher frequency of enuresis: 65% versus 9% (p = 0.001) and urinary tract infections: 18% versus 3% (p = 0.012). Girls with HD reported enuresis more frequently (60%) than healthy girls (7%) (p = 0.001). Children with HD with constipation reported enuresis more frequently (p = 0.038). Conclusions: Urinary tract anomalies and dysfunction deserve attention in the follow-up of children with HD. We suggest screening for urinary tract anomalies and urinary tract symptoms in follow-up of children with HD. Type of study: Treatment study. Level: III.
(Less)
- author
- Granéli, C.
LU
; Marschall Sima, H.
; Börjesson, A.
LU
; Hagelsteen, K.
LU
; Arnbjörnsson, E.
LU
and Stenström, P.
LU
- organization
- publishing date
- 2019-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CAKUT, Hirschsprung disease, TERPT, Urinary tract
- in
- Journal of Pediatric Surgery
- volume
- 54
- issue
- 10
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85060277082
- pmid:30685200
- ISSN
- 0022-3468
- DOI
- 10.1016/j.jpedsurg.2018.12.006
- language
- English
- LU publication?
- yes
- id
- 5503b7f6-9149-468d-bdef-f0fb262192a9
- date added to LUP
- 2019-02-01 09:48:22
- date last changed
- 2024-04-30 00:08:46
@article{5503b7f6-9149-468d-bdef-f0fb262192a9,
abstract = {{<p>Background/Purpose: Urinary tract function in children with Hirschsprung disease (HD) is rarely considered. Aim: to evaluate the prevalence of urinary tract anomalies and dysfunction in children with HD compared to controls. Methods: This was an observational cross sectional case–control study. Children with HD who underwent transanal endorectal pull-through technique (TERPT) from 2005 to 2017 were invited to participate. Ultrasound of the urinary tract was performed postoperatively. Children > 4 years were asked to answer a urinary tract function questionnaire. Controls were age-matched healthy children. Ethical approval was obtained. Results: Seventy two children with HD and TERPT were included. Ultrasound was performed in 58 children (83%) post-TERPT. Ten anomalies were diagnosed in six children (10%). Structural anomalies included abnormal kidney size (7%), renal agenesis (2%), prominent calyces (2%) and renal pelvis anomaly (25). Probable acquired anomalies included hydronephrosis (2%), hydroureter (2%) and parenchymal damage (2%). One child had a prior nephrectomy owing to a Wilms’ tumor. All 37 children > 4 years (27 boys and 10 girls), median aged 8 years (range 4–12), answered the questionnaire as did 284 healthy controls (144 boys and 140 girls). Boys with HD reported a higher frequency of enuresis: 65% versus 9% (p = 0.001) and urinary tract infections: 18% versus 3% (p = 0.012). Girls with HD reported enuresis more frequently (60%) than healthy girls (7%) (p = 0.001). Children with HD with constipation reported enuresis more frequently (p = 0.038). Conclusions: Urinary tract anomalies and dysfunction deserve attention in the follow-up of children with HD. We suggest screening for urinary tract anomalies and urinary tract symptoms in follow-up of children with HD. Type of study: Treatment study. Level: III.</p>}},
author = {{Granéli, C. and Marschall Sima, H. and Börjesson, A. and Hagelsteen, K. and Arnbjörnsson, E. and Stenström, P.}},
issn = {{0022-3468}},
keywords = {{CAKUT; Hirschsprung disease; TERPT; Urinary tract}},
language = {{eng}},
number = {{10}},
pages = {{2012--2016}},
publisher = {{Elsevier}},
series = {{Journal of Pediatric Surgery}},
title = {{Urinary tract anomalies and urinary tract dysfunction in children with Hirschsprung disease—Is follow-up indicated?}},
url = {{http://dx.doi.org/10.1016/j.jpedsurg.2018.12.006}},
doi = {{10.1016/j.jpedsurg.2018.12.006}},
volume = {{54}},
year = {{2019}},
}