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Insights into pathophysiology, biomarkers, and therapeutics in tauopathies : Proceedings of the Tau2024 Global Conference

Frost, Bess ; Rowe, James B. ; Akinyemi, Rufus O. ; Abisambra, Jose F. ; Ashton, Nicholas J. ; Brendel, Matthias ; Buée, Luc ; Butler, David ; Carrillo, Maria C. and Chung, Peter , et al. (2025) In Alzheimer's and Dementia 21(5).
Abstract

Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the Alzheimer's Association, CurePSP, and Rainwater Charitable Foundation, showcased these efforts by bringing together researchers and experts worldwide to discuss the latest advancements in tau research. The conference aimed to attract talent and funding to study tauopathies, particularly among early-career researchers, and to foster interdisciplinary alignment and collaboration around challenges in tau research. In this manuscript, we summarize proceedings of the Tau2024 Global Conference, covering a... (More)

Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the Alzheimer's Association, CurePSP, and Rainwater Charitable Foundation, showcased these efforts by bringing together researchers and experts worldwide to discuss the latest advancements in tau research. The conference aimed to attract talent and funding to study tauopathies, particularly among early-career researchers, and to foster interdisciplinary alignment and collaboration around challenges in tau research. In this manuscript, we summarize proceedings of the Tau2024 Global Conference, covering a wide range of topics, including lived experiences of individuals with genetic forms of tauopathies, global perspectives on tauopathies, and molecular mechanisms, brain microenvironments, biomarker developments, clinical trials, and therapeutic approaches to tauopathies. Through international, collaborative efforts, innovative research, and a commitment to inclusivity, researchers worldwide have demonstrated transformative breakthroughs toward diagnosing, treating, and, ultimately, preventing tau-related diseases. Highlights: The Tau2024 Global Conference presented updates and advances in tau research. Blood-based biomarkers offer specificity and longitudinal monitoring capabilities. There are a range of targetable mechanisms in the cascade of pathogenesis. International collaboration is vital to address disparities in tauopathies.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, neurodegenerative disease, tau disorder, tau protein, tauopathies
in
Alzheimer's and Dementia
volume
21
issue
5
article number
e70078
publisher
Wiley
external identifiers
  • scopus:105006898800
  • pmid:40437880
ISSN
1552-5260
DOI
10.1002/alz.70078
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
id
55b4de53-1414-4067-b340-d2c6a96d616f
date added to LUP
2025-08-05 15:27:58
date last changed
2025-08-07 08:55:24
@article{55b4de53-1414-4067-b340-d2c6a96d616f,
  abstract     = {{<p>Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the Alzheimer's Association, CurePSP, and Rainwater Charitable Foundation, showcased these efforts by bringing together researchers and experts worldwide to discuss the latest advancements in tau research. The conference aimed to attract talent and funding to study tauopathies, particularly among early-career researchers, and to foster interdisciplinary alignment and collaboration around challenges in tau research. In this manuscript, we summarize proceedings of the Tau2024 Global Conference, covering a wide range of topics, including lived experiences of individuals with genetic forms of tauopathies, global perspectives on tauopathies, and molecular mechanisms, brain microenvironments, biomarker developments, clinical trials, and therapeutic approaches to tauopathies. Through international, collaborative efforts, innovative research, and a commitment to inclusivity, researchers worldwide have demonstrated transformative breakthroughs toward diagnosing, treating, and, ultimately, preventing tau-related diseases. Highlights: The Tau2024 Global Conference presented updates and advances in tau research. Blood-based biomarkers offer specificity and longitudinal monitoring capabilities. There are a range of targetable mechanisms in the cascade of pathogenesis. International collaboration is vital to address disparities in tauopathies.</p>}},
  author       = {{Frost, Bess and Rowe, James B. and Akinyemi, Rufus O. and Abisambra, Jose F. and Ashton, Nicholas J. and Brendel, Matthias and Buée, Luc and Butler, David and Carrillo, Maria C. and Chung, Peter and Clelland, Claire D. and DeVos, Sarah L. and Diaz, Kristophe and Edelmayer, Rebecca M. and Elahi, Fanny M. and Ellajosyula, Ratnavalli and Ewen, Colin and Fontana, Igor Camargo and Galas, Marie Christine and Hansson, Oskar and Höglinger, Günter and Horie, Kanta and Ibanez, Agustín and Jacobs, Linde and Maina, Mahmoud B. and Malpetti, Maura and McDade, Eric and McEwan, Will and Montoliu-Gaya, Laia and Mummery, Catherine J. and Orr, Miranda E. and Rohrer, Jonathan D. and Rommel, Amy and Sastre, Carlos and Spires-Jones, Tara L. and Tee, Boon Lead and Viney, Tim J. and Walker, Jamie M. and Wegmann, Susanne and Wildsmith, Kristin and Yadav, Ravi and Mahinrad, Simin and Sexton, Claire}},
  issn         = {{1552-5260}},
  keywords     = {{Alzheimer's disease; neurodegenerative disease; tau disorder; tau protein; tauopathies}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{Wiley}},
  series       = {{Alzheimer's and Dementia}},
  title        = {{Insights into pathophysiology, biomarkers, and therapeutics in tauopathies : Proceedings of the Tau2024 Global Conference}},
  url          = {{http://dx.doi.org/10.1002/alz.70078}},
  doi          = {{10.1002/alz.70078}},
  volume       = {{21}},
  year         = {{2025}},
}