γ-aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis
(1985) In Neuroscience Letters 62(2). p.231-235- Abstract
Extracellular levels of striatal γ-aminobutyric acid (GABA) and taurine were monitored during insulin-induced hypoglycemia using microdialysis. At the onset of isoelectricity in the electroencephalogram (EEG), a transient 5-fold increase in the levels of GABA occurred. Taurine levels increased 5 min following the onset of isoelectricity and continued to increase during the entire isoelectric period. The results demonstrate that events associated with the onset of isoelectricity during hypoglycemia trigger an increase in extracellular concentrations of GABA and taurine. The discrepancy in time-course of these changes may reflect differences in compartmentation, function and metabolism of the two amino acids.
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https://lup.lub.lu.se/record/57c075e8-98ae-4c30-b9ae-185c46d8adf2
- author
- Tossman, Ulf ; Wieloch, Tadeusz LU and Ungerstedt, Urban
- organization
- publishing date
- 1985-12-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- extracellular concentration, hypoglycemia, microdialysis, rat, taurine, γ-aminobutyric acid
- in
- Neuroscience Letters
- volume
- 62
- issue
- 2
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:4088534
- scopus:0022368111
- ISSN
- 0304-3940
- DOI
- 10.1016/0304-3940(85)90360-X
- language
- English
- LU publication?
- yes
- id
- 57c075e8-98ae-4c30-b9ae-185c46d8adf2
- date added to LUP
- 2019-06-13 17:48:14
- date last changed
- 2024-01-01 10:34:46
@article{57c075e8-98ae-4c30-b9ae-185c46d8adf2, abstract = {{<p>Extracellular levels of striatal γ-aminobutyric acid (GABA) and taurine were monitored during insulin-induced hypoglycemia using microdialysis. At the onset of isoelectricity in the electroencephalogram (EEG), a transient 5-fold increase in the levels of GABA occurred. Taurine levels increased 5 min following the onset of isoelectricity and continued to increase during the entire isoelectric period. The results demonstrate that events associated with the onset of isoelectricity during hypoglycemia trigger an increase in extracellular concentrations of GABA and taurine. The discrepancy in time-course of these changes may reflect differences in compartmentation, function and metabolism of the two amino acids.</p>}}, author = {{Tossman, Ulf and Wieloch, Tadeusz and Ungerstedt, Urban}}, issn = {{0304-3940}}, keywords = {{extracellular concentration; hypoglycemia; microdialysis; rat; taurine; γ-aminobutyric acid}}, language = {{eng}}, month = {{12}}, number = {{2}}, pages = {{231--235}}, publisher = {{Elsevier}}, series = {{Neuroscience Letters}}, title = {{γ-aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis}}, url = {{http://dx.doi.org/10.1016/0304-3940(85)90360-X}}, doi = {{10.1016/0304-3940(85)90360-X}}, volume = {{62}}, year = {{1985}}, }