Tick exposure biomarkers : A One Health approach to new tick surveillance tools
Dziedziech, Alexis LU
; Krupa, Eva
; Persson, Kristina E.M.
LU
; Paul, Richard
and Bonnet, Sarah
(2024)
In Current Research in Parasitology and Vector-Borne Diseases
6.
- Abstract
The spread of tick-borne disease (TBD) is escalating globally, driven by climate change and socio-economic shifts, underlining the urgency to improve surveillance, diagnostics, and control strategies. Ticks can transmit a range of pathogens increasing the risk of transmission of human and veterinary diseases such as Lyme disease, tick-borne encephalitis, theileriosis, anaplasmosis, or Crimean-Congo hemorrhagic fever. Surveillance methods play a crucial role in monitoring the spread of tick-borne pathogens (TBP). However, there are shortcomings in the current surveillance methods regarding risks related to ticks. Human-tick encounters offer a novel metric for disease risk assessment, integrating human behavior into traditional... (More)
The spread of tick-borne disease (TBD) is escalating globally, driven by climate change and socio-economic shifts, underlining the urgency to improve surveillance, diagnostics, and control strategies. Ticks can transmit a range of pathogens increasing the risk of transmission of human and veterinary diseases such as Lyme disease, tick-borne encephalitis, theileriosis, anaplasmosis, or Crimean-Congo hemorrhagic fever. Surveillance methods play a crucial role in monitoring the spread of tick-borne pathogens (TBP). However, there are shortcomings in the current surveillance methods regarding risks related to ticks. Human-tick encounters offer a novel metric for disease risk assessment, integrating human behavior into traditional surveillance models. However, to more reliably measure tick exposure, a molecular marker is needed. The identification of antibodies against arthropod salivary proteins as biomarkers for vector exposure represents a promising avenue for enhancing existing diagnostic and surveillance metrics. Here we explore how the use of tick saliva biomarkers targeting recombinant proteins and synthetic peptides could significantly improve the assessment of TBD transmission risk and the effectiveness of vector control measures. With focused efforts on creating a biomarker against tick exposure suitable for humans and domestic animals alike, tick surveillance, diagnosis and control would be more achievable and aid in reducing the mounting threat of TBP through a One Health lens.
(Less)
- author
- Dziedziech, Alexis
LU
; Krupa, Eva
; Persson, Kristina E.M.
LU
; Paul, Richard
and Bonnet, Sarah
- organization
- publishing date
- 2024-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antigenic peptides, Biomarker discovery, Biomarkers, Immunogenic peptides, Tick exposure, Tick saliva
- in
- Current Research in Parasitology and Vector-Borne Diseases
- volume
- 6
- article number
- 100212
- publisher
- Elsevier
- external identifiers
-
- pmid:39286798
- scopus:85202880986
- DOI
- 10.1016/j.crpvbd.2024.100212
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2024 The Authors
- id
- 57e0d9b6-f3bf-41f3-922e-c486b4fb831d
- date added to LUP
- 2024-10-17 11:53:16
- date last changed
- 2025-01-23 21:41:58
@article{57e0d9b6-f3bf-41f3-922e-c486b4fb831d,
abstract = {{<p>The spread of tick-borne disease (TBD) is escalating globally, driven by climate change and socio-economic shifts, underlining the urgency to improve surveillance, diagnostics, and control strategies. Ticks can transmit a range of pathogens increasing the risk of transmission of human and veterinary diseases such as Lyme disease, tick-borne encephalitis, theileriosis, anaplasmosis, or Crimean-Congo hemorrhagic fever. Surveillance methods play a crucial role in monitoring the spread of tick-borne pathogens (TBP). However, there are shortcomings in the current surveillance methods regarding risks related to ticks. Human-tick encounters offer a novel metric for disease risk assessment, integrating human behavior into traditional surveillance models. However, to more reliably measure tick exposure, a molecular marker is needed. The identification of antibodies against arthropod salivary proteins as biomarkers for vector exposure represents a promising avenue for enhancing existing diagnostic and surveillance metrics. Here we explore how the use of tick saliva biomarkers targeting recombinant proteins and synthetic peptides could significantly improve the assessment of TBD transmission risk and the effectiveness of vector control measures. With focused efforts on creating a biomarker against tick exposure suitable for humans and domestic animals alike, tick surveillance, diagnosis and control would be more achievable and aid in reducing the mounting threat of TBP through a One Health lens.</p>}},
author = {{Dziedziech, Alexis and Krupa, Eva and Persson, Kristina E.M. and Paul, Richard and Bonnet, Sarah}},
keywords = {{Antigenic peptides; Biomarker discovery; Biomarkers; Immunogenic peptides; Tick exposure; Tick saliva}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Current Research in Parasitology and Vector-Borne Diseases}},
title = {{Tick exposure biomarkers : A One Health approach to new tick surveillance tools}},
url = {{http://dx.doi.org/10.1016/j.crpvbd.2024.100212}},
doi = {{10.1016/j.crpvbd.2024.100212}},
volume = {{6}},
year = {{2024}},
}