Protocol for a Longitudinal Cohort Study to Understand Characteristics and Risk Factors Underlying Vibration-Controlled Transient Elastography-Diagnosed Metabolic Dysfunction-Associated Fatty Liver Disease Children
Yang, Fan ; Hu, Mengyuan ; Zhang, Haoyang LU
; Zheng, Xiaowei
; Chen, Limei
; Zhu, Lihong
and Zhang, Le
(2024)
In Diabetes, Metabolic Syndrome and Obesity
17.
p.4627-4639
- Abstract
- Background: Metabolic-associated steatotic liver disease (MASLD) is a novel term proposed in 2023 to replace non-alcoholic fatty liver disease (NAFLD) with the aim of better reflecting its pathogenesis and clinical manifestations. Vibration-controlled transient elastography (VCTE) is an evidence-based, non-invasive imaging device used to evaluate liver fat deposition and fibrosis. It can effectively detect liver fat infiltration greater than 5%, which is much higher than the previous ultrasound detection rate (it is difficult to detect liver fat deposition below 30%). Nevertheless, the prevalence and characteristics of MASLD children diagnosed based on these updated criteria are currently not well established.
Methods: Currently, a... (More) - Background: Metabolic-associated steatotic liver disease (MASLD) is a novel term proposed in 2023 to replace non-alcoholic fatty liver disease (NAFLD) with the aim of better reflecting its pathogenesis and clinical manifestations. Vibration-controlled transient elastography (VCTE) is an evidence-based, non-invasive imaging device used to evaluate liver fat deposition and fibrosis. It can effectively detect liver fat infiltration greater than 5%, which is much higher than the previous ultrasound detection rate (it is difficult to detect liver fat deposition below 30%). Nevertheless, the prevalence and characteristics of MASLD children diagnosed based on these updated criteria are currently not well established.
Methods: Currently, a prospective multi-center population-based cohort study is being conducted in Wuxi, China, spanning from 2023 to 2035, involving 5600 children from four primary schools. Throughout the study’s baseline and follow-up periods, yearly physical examinations, laboratory tests, VCTE assessments, and bioelectrical impedance analysis are being conducted to measure MASLD-related biomarkers. Additionally, a questionnaire is being administered to inquire about dietary habits. MASLD is being diagnosed based on clinical and laboratory criteria, and the corresponding prevalence is being assessed.
Results: Recruitment began in March 13, 2023. To date, 1475 participants have completed the physical examination and questionnaire survey.
Discussion: Our study investigated the prevalence of MASLD and its influencing factors in Chinese school-age children and adolescents. By collecting and analyzing data from physical examinations and survey questionnaires, it may propose new avenues for guiding the treatment and early-stage prevention of MASLD in children. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/59314917-8f96-4eda-bfc5-88998fc99721
- author
- Yang, Fan
; Hu, Mengyuan
; Zhang, Haoyang
LU
; Zheng, Xiaowei
; Chen, Limei
; Zhu, Lihong
and Zhang, Le
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- keywords
- cohort study, incidence, MASLD, student, VCTE
- in
- Diabetes, Metabolic Syndrome and Obesity
- volume
- 17
- pages
- 13 pages
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- pmid:39649758
- scopus:85211773914
- DOI
- 10.2147/DMSO.S492809
- language
- English
- LU publication?
- no
- id
- 59314917-8f96-4eda-bfc5-88998fc99721
- date added to LUP
- 2024-12-09 15:36:03
- date last changed
- 2025-04-16 20:03:44
@article{59314917-8f96-4eda-bfc5-88998fc99721,
abstract = {{Background: Metabolic-associated steatotic liver disease (MASLD) is a novel term proposed in 2023 to replace non-alcoholic fatty liver disease (NAFLD) with the aim of better reflecting its pathogenesis and clinical manifestations. Vibration-controlled transient elastography (VCTE) is an evidence-based, non-invasive imaging device used to evaluate liver fat deposition and fibrosis. It can effectively detect liver fat infiltration greater than 5%, which is much higher than the previous ultrasound detection rate (it is difficult to detect liver fat deposition below 30%). Nevertheless, the prevalence and characteristics of MASLD children diagnosed based on these updated criteria are currently not well established.<br/>Methods: Currently, a prospective multi-center population-based cohort study is being conducted in Wuxi, China, spanning from 2023 to 2035, involving 5600 children from four primary schools. Throughout the study’s baseline and follow-up periods, yearly physical examinations, laboratory tests, VCTE assessments, and bioelectrical impedance analysis are being conducted to measure MASLD-related biomarkers. Additionally, a questionnaire is being administered to inquire about dietary habits. MASLD is being diagnosed based on clinical and laboratory criteria, and the corresponding prevalence is being assessed.<br/>Results: Recruitment began in March 13, 2023. To date, 1475 participants have completed the physical examination and questionnaire survey.<br/>Discussion: Our study investigated the prevalence of MASLD and its influencing factors in Chinese school-age children and adolescents. By collecting and analyzing data from physical examinations and survey questionnaires, it may propose new avenues for guiding the treatment and early-stage prevention of MASLD in children.}},
author = {{Yang, Fan and Hu, Mengyuan and Zhang, Haoyang and Zheng, Xiaowei and Chen, Limei and Zhu, Lihong and Zhang, Le}},
keywords = {{cohort study; incidence; MASLD; student; VCTE}},
language = {{eng}},
pages = {{4627--4639}},
publisher = {{Dove Medical Press Ltd.}},
series = {{Diabetes, Metabolic Syndrome and Obesity}},
title = {{Protocol for a Longitudinal Cohort Study to Understand Characteristics and Risk Factors Underlying Vibration-Controlled Transient Elastography-Diagnosed Metabolic Dysfunction-Associated Fatty Liver Disease Children}},
url = {{http://dx.doi.org/10.2147/DMSO.S492809}},
doi = {{10.2147/DMSO.S492809}},
volume = {{17}},
year = {{2024}},
}