OGRDB : a reference database of inferred immune receptor genes
Lees, William ; Busse, Christian E. ; Corcoran, Martin ; Ohlin, Mats LU
; Scheepers, Cathrine
; Matsen, Frederick A.
; Yaari, Gur
; Watson, Corey T.
; Collins, Andrew
and Shepherd, Adrian J.
(2020)
In Nucleic Acids Research
48(D1).
p.964-970
- Abstract
High-throughput sequencing of the adaptive immune receptor repertoire (AIRR-seq) is providing unprecedented insights into the immune response to disease and into the development of immune disorders. The accurate interpretation of AIRR-seq data depends on the existence of comprehensive germline gene reference sets. Current sets are known to be incomplete and unrepresentative of the degree of polymorphism and diversity in human and animal populations. A key issue is the complexity of the genomic regions in which they lie, which, because of the presence of multiple repeats, insertions and deletions, have not proved tractable with short-read whole genome sequencing. Recently, tools and methods for inferring such gene sequences from AIRR-seq... (More)
High-throughput sequencing of the adaptive immune receptor repertoire (AIRR-seq) is providing unprecedented insights into the immune response to disease and into the development of immune disorders. The accurate interpretation of AIRR-seq data depends on the existence of comprehensive germline gene reference sets. Current sets are known to be incomplete and unrepresentative of the degree of polymorphism and diversity in human and animal populations. A key issue is the complexity of the genomic regions in which they lie, which, because of the presence of multiple repeats, insertions and deletions, have not proved tractable with short-read whole genome sequencing. Recently, tools and methods for inferring such gene sequences from AIRR-seq datasets have become available, and a community approach has been developed for the expert review and publication of such inferences. Here, we present OGRDB, the Open Germline Receptor Database (https://ogrdb.airr-community.org), a public resource for the submission, review and publication of previously unknown receptor germline sequences together with supporting evidence.
(Less)
- author
- Lees, William
; Busse, Christian E.
; Corcoran, Martin
; Ohlin, Mats
LU
; Scheepers, Cathrine
; Matsen, Frederick A.
; Yaari, Gur
; Watson, Corey T.
; Collins, Andrew
and Shepherd, Adrian J.
- author collaboration
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nucleic Acids Research
- volume
- 48
- issue
- D1
- pages
- 964 - 970
- publisher
- Oxford University Press
- external identifiers
-
- pmid:31566225
- scopus:85077665773
- ISSN
- 1362-4962
- DOI
- 10.1093/nar/gkz822
- language
- English
- LU publication?
- yes
- id
- 5932d5a6-a475-40b9-854d-646ea81f014e
- date added to LUP
- 2020-01-27 11:16:18
- date last changed
- 2024-01-16 19:35:08
@article{5932d5a6-a475-40b9-854d-646ea81f014e,
abstract = {{<p>High-throughput sequencing of the adaptive immune receptor repertoire (AIRR-seq) is providing unprecedented insights into the immune response to disease and into the development of immune disorders. The accurate interpretation of AIRR-seq data depends on the existence of comprehensive germline gene reference sets. Current sets are known to be incomplete and unrepresentative of the degree of polymorphism and diversity in human and animal populations. A key issue is the complexity of the genomic regions in which they lie, which, because of the presence of multiple repeats, insertions and deletions, have not proved tractable with short-read whole genome sequencing. Recently, tools and methods for inferring such gene sequences from AIRR-seq datasets have become available, and a community approach has been developed for the expert review and publication of such inferences. Here, we present OGRDB, the Open Germline Receptor Database (https://ogrdb.airr-community.org), a public resource for the submission, review and publication of previously unknown receptor germline sequences together with supporting evidence.</p>}},
author = {{Lees, William and Busse, Christian E. and Corcoran, Martin and Ohlin, Mats and Scheepers, Cathrine and Matsen, Frederick A. and Yaari, Gur and Watson, Corey T. and Collins, Andrew and Shepherd, Adrian J.}},
issn = {{1362-4962}},
language = {{eng}},
number = {{D1}},
pages = {{964--970}},
publisher = {{Oxford University Press}},
series = {{Nucleic Acids Research}},
title = {{OGRDB : a reference database of inferred immune receptor genes}},
url = {{http://dx.doi.org/10.1093/nar/gkz822}},
doi = {{10.1093/nar/gkz822}},
volume = {{48}},
year = {{2020}},
}